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PREDICT is an observational study following adults with an unprovoked seizure or epilepsy in the health care region of western Sweden. The objective is to identify biomarkers and/or genetic predisposition of relevance for diagnosis and/or treatment of epilepsy and study the long-term prognosis and consequences of epilepsy.
Adults over 18 years of age, with an unprovoked seizure in the last year or epilepsy, resident in the health care region of western Sweden (VGR) at the time of inclusion.
Baseline data and outcome variables are collected from several patient registries: the electronic medical records system in the health care region VGR and Swedish National Registers of healthcare, income, and employment managed by The National Board of Health and Welfare or Statistics Sweden, both of which are government agencies.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Adults with epilepsy | Adults over 18 years of age, with an unprovoked seizure in the last year or epilepsy, resident in VGR at the time of inclusion. Languages available: Swedish, English, Arabic. Based on the clinical information, patients can be categorized into relevant groups; single seizure, seizure-free with epilepsy, and drug-resistant epilepsy. Subgroups may also be selected based on age, sex, epilepsy sub-diagnosis, cause of epilepsy, use of a particular antiepileptic drug, or experience of a particular side effect. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Seizure status | Other | We will collect information on first seizure ever, last seizure ever, number of seizure in last two months. |
|
| Measure | Description | Time Frame |
|---|---|---|
| epilepsy | more than one seizure after first seizure | baseline and years 1,2,3,4,5,6,7,8,9,10 |
| seizure status | the number of seizures in last two months and overall | baseline and years 1,2,3,4,5,6,7,8,9,10 |
| drug resistant epilepsy | epilepsy that has not responded to two antiepileptic drugs | baseline and years 1,2,3,4,5,6,7,8,9,10 |
| severe side effects of antiepileptic drug | baseline and years 1,2,3,4,5,6,7,8,9,10 | |
| psychosocial outcomes | employment, marital status, income, sick leave | baseline and years 1,2,3,4,5,6,7,8,9,10 |
| Measure | Description | Time Frame |
|---|---|---|
| received health care | the number of visits for epilepsy, missed appointments, time intervals between visits | baseline and years 1,2,3,4,5,6,7,8,9,10 |
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Inclusion Criteria:
Exclusion Criteria:
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Adults with an unprovoked seizure or epilepsy, resident in VGR at inclusion.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Johan Zelano, MD PhD | Contact | +46313421000 | johan.zelano@vgregion.se |
| Name | Affiliation | Role |
|---|---|---|
| Johan Zelano, MD PhD | Sahlgrenska University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Södra Älvsborgs Sjukhus | Recruiting | Borås | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42161148 | Derived | Karlander M, Akel S, Idegard A, Andersson K, Zetterberg H, Larsson D, Zelano J. Civilian post-traumatic epilepsy: Clinical and socioeconomic characteristics. Epilepsy Behav. 2026 Sep;182:111107. doi: 10.1016/j.yebeh.2026.111107. Epub 2026 May 20. | |
| 41864089 | Derived | Andersson K, Boxum M, Srikrishna M, Malac M, Bjorkman-Burtscher IM, Scholl M, Zelano J. Gray matter volume associations with clinical outcomes in epilepsy: A regional cohort study. Epilepsy Res. 2026 May;223:107781. doi: 10.1016/j.eplepsyres.2026.107781. Epub 2026 Mar 20. |
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The data will be protected by privacy laws and cannot be shared even if anonymized, because of the high resolution of data.
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| ID | Term |
|---|---|
| D004827 | Epilepsy |
| D012640 | Seizures |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D009461 | Neurologic Manifestations |
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| ID | Term |
|---|---|
| D003710 | Demography |
| D003695 | Delivery of Health Care |
| ID | Term |
|---|---|
| D011154 | Population Characteristics |
| D015991 | Epidemiologic Measurements |
| D011634 | Public Health |
| D004778 | Environment and Public Health |
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Blood samples, and for some individuals cerebrospinal fluid (if lumbar puncture is indicated for clinical reasons, extra csf will be collected).
| Tests | Diagnostic Test | We will collect results from imaging, electroencephalogram, and laboratory tests. |
|
| Epilepsy | Other | We will collect information on risk factors of epilepsy, cause of epilepsy, epilepsy type/syndrome, medications tried, if the epilepsy is drug resistent, side effects of antiepileptic drugs. |
|
| Demographics and psychosocial | Other | We will collect information on age, sex, date of death if applicable, marital status, education level, income type, driving status, employment, benefits, sick leave, number of household members. |
|
| Health care | Other | We will collect information on received health care; visit dates, caregiver, dispensation dates of antiepileptic drugs |
|
| Sahlgrenska University Hospital | Recruiting | Gothenburg | 41345 | Sweden |
|
| Sjukhusen i Väster | Recruiting | Gothenburg | Sweden |
|
| 39826304 | Derived | Andersson K, Akel S, Asztely F, Larsson D, Zetterberg H, Zelano J. Higher plasma total tau concentrations among patients reporting CNS-related side effects from antiseizure medication. Seizure. 2025 Feb;125:99-105. doi: 10.1016/j.seizure.2025.01.015. Epub 2025 Jan 13. |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010346 | Patient Care Management |
| D006298 | Health Services Administration |
| D017530 | Health Care Quality, Access, and Evaluation |