Since the introduction of Giemsa stain in 1904 until today, malaria microscopy has been the standard of practice for malaria diagnosis. However, microscopic detection of malaria parasites is labour-intensive, time-consuming and expertise-demanding. Moreover, the slide interpretation is highly dependent on the staining technique and the technician's expertise.

To address these, multiple organisations have developed next generation microscopes to move towards a next generation microscope that can improve slide preparation, interpretation or data collection, or a combination of these features.

In this study, a prospective evaluation of miLab™ and other next generation automated microscope solutions as well as a malaria rapid diagnostic test (RDT) reader app will be performed in malaria-endemic countries to assess their clinical performance for detection of malaria clinical cases at POC.

Inclusion Criteria:

• Aged 5 years or older
• Malaria status (positive or negative) established by microscopy at the health facility, where the patient is presenting
• Freely agreeing to participate by signing an informed consent form (adults aged 18 and older and parent/legal guardian of a child) and providing assent (children aged 13-17)
• Willing to provide finger prick blood sample at enrollment

Exclusion Criteria:

• Having received antimalarial treatment during the preceding four-week period
• Presence of symptoms and signs of severe disease and/or central nervous system infections, as defined by WHO guidelines

Patients with symptoms suggestive of malaria seeking clinical care in health facilities