CLAD: Finding Biomarkers to Predict Rejection and/ or Outcome After Lung Transplantation

CLAD: Finding Biomarkers to Predict Rejection and/ or Outcome After Lung Transplantation

Lung transplantation is the ultimate treatment for end stage lung diseases. Survival after lung transplantation is limited mainly due to the development of chronic allograft dysfunction (CLAD). Both acute cellular rejection and primary grade dysfunction (PGD) have been associated with the development of CLAD. In this study we will investigate multiple prognostic factors that influence long term survival after lung transplantation with a specific interest in PGD, acute rejection and the development of CLAD.

At specific time points (according to protocol) exhaled breath, blood specimens, bronchoalveolar lavage and biopsies will be collected. These will be analyzed in an attempt to identify possible biomarkers that will predict the development of PGD and/or CLAD.

Inclusion Criteria:

• all lung transplant recipients > 18 years signed ICF (informed consent form)

Exclusion Criteria:

• none