Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle

Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle

The purpose of the study is to evaluate the link between insulin resistance and alterations in skeletal muscle mitochondrial redox homeostasis

Inclusion Criteria:

• Body mass index (BMI) ≥25 and <40 kg/m2
• Fasting plasma glucose ≥ 5.6 mmol/L or HbA1c ≥ 5.7%
• HOMA2-IR > 1.4
• VO2max <45 ml/kg/min

Exclusion Criteria:

• Treatment with >2 antidiabetic medications
• Insulin usage
• Chronic disease deemed by the study responsible medical doctor to interfere with any part of the study
• Chronic use of prescription medicine deemed by the study responsible medical doctor to interfere with any part of the study
• Smoking