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| ID | Type | Description | Link |
|---|---|---|---|
| P01AG019783 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| Sound Physicians | OTHER |
| National Institute on Aging (NIA) | NIH |
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Hopewell Hospitalist is a theory-based adventure video game designed to increase the likelihood that a physician will engage in an advance care planning (ACP) conversation with a patient over the age of 65. Drawing on the theory of narrative engagement, players assume the persona of a hospitalist and navigate a series of clinical encounters with seriously-ill patients over the age of 65. Players experience the consequences of having (or not having) ACP conversations in a timely fashion. The planned study is a pragmatic stepped-wedge crossover phase III trial testing the efficacy of Hopewell Hospitalist for increasing ACP rates measured by ACP billing frequency.
Introduction: Fewer than half of all people in the U.S. have a documented advance care plan, such as an advance directive, despite their importance in ensuring high-quality care at the end-of-life. Hospitalization offers an opportunity for physicians to initiate advance care planning (ACP) conversations. Despite expert recommendations, hospital-based physicians (hospitalists) do not routinely engage in these conversations, reserving them for the critically ill.
The objective of this study is to test the effect of a novel behavioral intervention on the incidence of ACP conversations by hospitalists practicing at a stratified random sample of hospitals drawn from 220 US acute care hospitals staffed by a large, nationwide acute care physician practice with an ongoing ACP quality improvement initiative.
Methods and analysis: We developed Hopewell Hospitalist, a theory-based adventure video game, to modify physicians' attitudes towards ACP conversations, and to increase their motivation for engaging in them. Drawing on the theory of narrative engagement, players assume the persona of Andy Jordan, a hospitalist who accepts a new job in a small town. Through a series of clinical encounters with seriously-ill patients over the age of 65, players experience the consequences of having (or not having) ACP conversations in a timely fashion. The planned study is a pragmatic stepped-wedge crossover phase III trial, testing the efficacy of Hopewell Hospitalist for increasing ACP conversations. We will randomize 40 hospitals to the month (step) in which they receive the intervention. We aim to recruit 30 hospitalists from up to 8 hospitals each step to complete the intervention, playing Hopewell Hospitalist for at least 2 hours on an iPad pre-loaded with the game. The primary outcome is ACP billing for patients age 65 and older managed by participating hospitalists. We hypothesize that the intervention will increase ACP billing in the quarter after dissemination, and have 80% power to detect a 1% absolute increase and 99% power to detect a 3.5% absolute increase.
Ethics and dissemination: Dartmouth's Committee for the Protection of Human Subjects has approved the study protocol, which is registered on clinicaltrials.gov. We will disseminate the results through manuscripts and the trials website. Hopewell Hospitalist will be made available on the iOS Application Store for download, free of cost, at the conclusion of the trial.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Usual Care Control | No Intervention | The control arm occurred prior to receipt of the video game intervention. Each hospital group 'crossed over' from control to intervention at a randomized time point based on their assignment to the 'step' of the trial. | |
| Video Game Intervention | Experimental | Each hospital group 'crossed over' from control to intervention at a randomized time point. Physicians working at these hospitals, who agreed to participate in the trial, received a study iPad and were asked to play the video game loaded on the iPad for a minimum of 2 hours. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hopewell Hospitalist Video Game | Behavioral | Hopewell Hospitalist is a customized theory-based adventure video game that uses narrative engagement to educate physician players on advance care planning to increase physicians' likelihood of engaging in and billing for ACP conversations. |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of Patients With Advance Care Planning Bills | Percentage of advance care planning bills submitted by physicians in the trial for patients over the age of 65 in the period before and after the roll-out of the video game intervention at their hospital. Advance care planning bills are defined as the presence/absence of ACP charges (Medicare billing codes 99497 or 99498) during a patient's hospitalization. | 11 months |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of Patients Who Died While in Hospital | Number of patients who died in the pre-intervention and post-intervention period/total number of patients for both periods | 11 months |
| Percentage of Patients Readmitted in 7 Days |
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Hospital Inclusion Criteria:
Hospital Exclusion Criteria:
Hospitalist Inclusion Criteria:
Hospitalist Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Amber Barnato, MD, MPH, MS | Dartmouth-Hitchcock Medical Center and Geisel School of Medicine� | Principal Investigator |
| Deepika Mohan, MD, MPH | University of Pittsburgh | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | 03766 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34645515 | Background | Mohan D, MacMartin MA, Chelen JSC, Maezes CB, Barnato AE. Development of a theory-based video-game intervention to increase advance care planning conversations by healthcare providers. Implement Sci Commun. 2021 Oct 13;2(1):117. doi: 10.1186/s43058-021-00216-8. | |
| 33753443 | Background | Mohan D, O'Malley AJ, Chelen J, MacMartin M, Murphy M, Rudolph M, Barnato A. Videogame intervention to increase advance care planning conversations by hospitalists with older adults: study protocol for a stepped-wedge clinical trial. BMJ Open. 2021 Mar 22;11(3):e045084. doi: 10.1136/bmjopen-2020-045084. |
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We will share de-identified participant data and supporting information with other researchers upon request to the PI.
Upon publication of the planned manuscripts. Data will be retained through February 2028.
Data will require completion of a data use agreement with Dartmouth.
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There was a minimum three month (maximum 7-month) run-in period prior to the exposure of patients to the physicians enrolled in the intervention. We distinguish below between physician participants who enrolled in the trial, and patient participants who were treated by physicians in the trial. The latter group were unconsented.
Dates: July 2020-May 2021 Types of location: acute care hospitals
| ID | Title | Description |
|---|---|---|
| FG000 | Step 1 | First group of hospitals randomized to receive the intervention. Pre-intervention phase lasted from Months 0-3; post-intervention phase lasted from Months 4-11 |
| FG001 | Step 2 | Second group of hospitals randomized to receive the intervention. Pre-intervention phase lasted from Months 0-4; post-intervention phase lasted from Months 5-11 |
| FG002 | Step 3 | Third group of hospitals randomized to receive the intervention. Pre-intervention phase lasted from Months 0-5; post-intervention phase lasted from Months 6-11 |
| FG003 | Step 4 | Fourth group of hospitals randomized to receive the intervention. Pre-intervention phase lasted from Months 0-6; post-intervention phase lasted from Months 7-11 |
| FG004 | Step 5 | Fifth group of hospitals randomized to receive the intervention. Pre-intervention phase lasted from Months 0-7; post-intervention phase lasted from Months 8-11 |
| Title | Milestones | Reasons Not Completed | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pre-intervention |
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| Post-intervention |
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physicians who enrolled in the trial
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| ID | Title | Description |
|---|---|---|
| BG000 | Intervention | The control arm occurs prior to receipt of the video game intervention. Each hospital group 'crosses over' from control to intervention at a randomized time point. |
| Units | Counts |
|---|---|
| Participants |
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| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Percentage of Patients With Advance Care Planning Bills | Percentage of advance care planning bills submitted by physicians in the trial for patients over the age of 65 in the period before and after the roll-out of the video game intervention at their hospital. Advance care planning bills are defined as the presence/absence of ACP charges (Medicare billing codes 99497 or 99498) during a patient's hospitalization. | We analyzed outcomes for patients over 65 admitted for an acute illness, and treated by a trial participant in the pre- and post-intervention periods. | Posted | Count of Participants | Participants | 11 months |
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11 months
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Pre-intervention | The control arm occurs prior to receipt of the video game intervention. |
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Heterogeneity of treatment effect across steps of the trial, suggesting the possibility of confounding secondary to the impact of COVID on hospital conditions.
Other limitations include: 1) generalizability of the results; 2) bias from non-random patterns of missingness in the data; 3) failure to systematically evaluate the fidelity and implementation of the intervention as planned due to COVID.
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr. Amber E. Barnato | Dartmouth-Hitchcock | 603-646-5609 | Amber.Barnato@dartmouth.edu |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Mar 17, 2020 | Nov 22, 2022 | Prot_001.pdf |
| SAP | No | Yes | No | Statistical Analysis Plan | Nov 11, 2021 | Nov 22, 2022 | SAP_002.pdf |
| ICF | No | No | Yes | Informed Consent Form | Mar 11, 2020 | Nov 22, 2022 | ICF_003.pdf |
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A stepped wedge crossover trial randomizing physician participants at the group level (i.e., hospital). Each hospital group 'crossed over' from control to intervention at a randomized time point.
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A hospital's treatment assignment was masked during analysis.
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Number of patients readmitted within 7 days/Total number of patients treated in the pre-intervention and post-intervention periods
| 11 months |
| Percentage of Patients Readmitted Within 30-days | Number of patients readmitted within 30-days/Total number of patients in the pre-intervention and post-intervention periods | 11 months |
| Percentage of Patients Who Received Critical Care | Number of patients who received critical care while admitted/total number of patients admitted in the pre-intervention and post-intervention periods | 11 months |
| Length of Stay | Duration of hospitalization for patients treated in the pre-intervention and post-intervention periods | 11 months |
| 37429972 | Derived | Mohan D, O'Malley AJ, Chelen J, MacMartin M, Murphy M, Rudolph M, Engel JA, Barnato AE. Using a Video Game Intervention to Increase Hospitalists' Advance Care Planning Conversations with Older Adults: a Stepped Wedge Randomized Clinical Trial. J Gen Intern Med. 2023 Nov;38(14):3224-3234. doi: 10.1007/s11606-023-08297-y. Epub 2023 Jul 10. |
| Patient Participants Treated by Enrolled Physicians |
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| COMPLETED | We used an intention to treat analysis, so all physician participants enrolled in the trial were deemed to have 'completed' the intervention. There was loss to follow up in only 1 step (Step 2). Two physicians here did not complete all study tasks. |
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| NOT COMPLETED |
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| years |
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| Sex: Female, Male | Count of Participants | Participants |
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| Ethnicity (NIH/OMB) | Count of Participants | Participants |
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| Race (NIH/OMB) | Count of Participants | Participants |
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| Region of Enrollment | Number | participants |
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| Physician Experience in Years of Practice | Mean | Standard Deviation | years |
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| How frequently do you use the Advance Care Planning [ACP] billing codes | Count of Participants | Participants |
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| Post-intervention |
Patients treated by trial participants after the roll-out of the intervention at their hospital. |
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| Secondary | Percentage of Patients Who Died While in Hospital | Number of patients who died in the pre-intervention and post-intervention period/total number of patients for both periods | Posted | Count of Participants | Participants | 11 months |
|
|
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| Secondary | Percentage of Patients Readmitted in 7 Days | Number of patients readmitted within 7 days/Total number of patients treated in the pre-intervention and post-intervention periods | Posted | Count of Participants | Participants | 11 months |
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|
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| Secondary | Percentage of Patients Readmitted Within 30-days | Number of patients readmitted within 30-days/Total number of patients in the pre-intervention and post-intervention periods | Posted | Count of Participants | Participants | 11 months |
|
|
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| Secondary | Percentage of Patients Who Received Critical Care | Number of patients who received critical care while admitted/total number of patients admitted in the pre-intervention and post-intervention periods | Posted | Count of Participants | Participants | 11 months |
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| Secondary | Length of Stay | Duration of hospitalization for patients treated in the pre-intervention and post-intervention periods | Posted | Mean | Standard Deviation | Days | 11 months |
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| 0 |
| 163 |
| 0 |
| 163 |
| 0 |
| 163 |
| EG001 | Post-Intervention | Physicians in the hospital group receive an iPad with the intervention pre-loaded, that they are asked to play for at least 2 hours. Hopewell Hospitalist Video Game: Hopewell Hospitalist is a customized theory-based adventure video game that uses narrative engagement to educate physician players on advance care planning to increase physicians' likelihood of engaging in and billing for ACP conversations. | 0 | 163 | 0 | 163 | 0 | 163 |
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