Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Istituto Universitario di Studi Superiori Pavia | OTHER |
Not provided
Not provided
Not provided
Not provided
Obstructive sleep apnoea is the most common sleep disorder in general population, and is often associated with cognitive deficit, mood disorders, hypertension, diabetes mellitus, excessive daytime somnolence, nicturia and an increased cardiovascular and metabolic risk. The gold standard of treatment is Continuous Positive Airway Pressure (CPAP), but the adherence is often poor. The aim of our study is to investigate the effort based-decision making in patients with OSA, pre and post CPAP treatment, as a possible cause of poor adherence.
Obstructive sleep apnea is a very common disease in general population (24% males; 9% females), characterized by frequent partial or total upper-airway collapse, intermittent hypoxia, arousal from sleep, change in blood pressure, excessive daytime sleepiness, cardiovascular and metabolic diseases, psychological and cognitive consequences. The gold standard treatment is Continuous Positive Airway Pressure (CPAP), but the adherence is often poor. Poor therapy adherence might be partially explained by executive deficits, decreasing the ability to plan and pursue longsighted behaviors entailing immediate costs/efforts. We investigate the cognitive function, in particular effort based-decision making and the relationship with excessive daytime somnolence and other cognitive function in a group of OSA patients and in control group. We assess cognitive function in OSA patients at the diagnosis moment and after six months of CPAP use.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CPAP Treatment | Experimental | Patients with OSA will undergo cognitive assessment before starting CPAP treatment and after six months of CPAP use. |
|
| Control Group | No Intervention | We will enrol a control group of subjects without sleep disorders and comparable to OSA patients for age and schooling. Control group will undergo cognitive assessment. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Continuous Positive Airway Pressure (CPAP) treatment | Device | Treatment of Obstructive sleep apnoea syndrome with CPAP |
|
| Measure | Description | Time Frame |
|---|---|---|
| Memory | Short and Long-term memory will be assessed with Digit span and California verbal learning test | Change will be assesd before starting CPAP and after six months of CPAP treatment |
| Executive Function | attentional and executive functioning will be assessed with Test of Attentional Performance (TAP) | Change will be assesd before starting CPAPT and after six months of CPAP treatment |
| Planning | Planning will be assessed with Tower of London | Change will be assesd before starting CPAPT and after six months of CPAP treatment |
| Response inhibition | Will be assessed with Test Go-nogo | Change will be assesd before starting CPAPT and after six months of CPAP treatment |
| Efforth decision making | Will be assesses with Rapid Serial Visual Presentation (RSVP) | Change will be assesd before starting CPAPT and after six months of CPAP treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Effect of CPAP treatment on memory | Administration of Digit span and California verbal Learning test | After six month of CPAP use |
| Effect of CPAP treatment on executive function | Administration of Test attentional Performance |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nicola Canessa, PhD | Contact | +39 0382 375845 | nicola.canessa@icsmaugeri.it |
| Name | Affiliation | Role |
|---|---|---|
| Nicola Canessa, PhD | IRCCS Istituti Clinici Scientifici Maugeri - Scuola superiore IUSS Pavia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| ICS Maugeri Pavia | Recruiting | Pavia | 27100 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30736887 | Background | Patil SP, Ayappa IA, Caples SM, Kimoff RJ, Patel SR, Harrod CG. Treatment of Adult Obstructive Sleep Apnea with Positive Airway Pressure: An American Academy of Sleep Medicine Clinical Practice Guideline. J Clin Sleep Med. 2019 Feb 15;15(2):335-343. doi: 10.5664/jcsm.7640. | |
| 21037021 | Background | Canessa N, Castronovo V, Cappa SF, Aloia MS, Marelli S, Falini A, Alemanno F, Ferini-Strambi L. Obstructive sleep apnea: brain structural changes and neurocognitive function before and after treatment. Am J Respir Crit Care Med. 2011 May 15;183(10):1419-26. doi: 10.1164/rccm.201005-0693OC. Epub 2010 Oct 29. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D020181 | Sleep Apnea, Obstructive |
| D001049 | Apnea |
| ID | Term |
|---|---|
| D012891 | Sleep Apnea Syndromes |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D020919 | Sleep Disorders, Intrinsic |
Not provided
Not provided
| ID | Term |
|---|---|
| D045422 | Continuous Positive Airway Pressure |
| D013812 | Therapeutics |
| ID | Term |
|---|---|
| D011175 | Positive-Pressure Respiration |
| D012121 | Respiration, Artificial |
| D058109 | Airway Management |
| D012138 | Respiratory Therapy |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| After six month of CPAP use |
| Effect of CPAP on planning | Adimnistration of Tower of London Test | After six month of CPAP use |
| Effect of CPAP on Response inhibition | administration of go no go Test | After six month of CPAP use |
| Effect of CPAP on effort decision making | Administration of Rapid Serial Visual Presentation (RSVP) test | After six month of CPAP use |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |