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| Name | Class |
|---|---|
| Haukeland University Hospital | OTHER |
| Addis Ababa University | OTHER |
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In this bi-directional program of education, training and research activities based on sustainable development goals aim is to develop cardiac surgery service in Ethiopia.
The aim is to evaluate the short and long-term outcome of cardiac surgery for rheumatic heart disease in a low-income country compared to individuals not offered cardiac surgery due to limited availability of the service. Second aim is to evaluate the quality of anticoagulant therapy in patients after cardiac surgery for rheumatic heart disease in a low-income country .
Our objectives are:
Population: Approximately 50 RHD patients operated by Our team at Addis Abeba University Hospital, Ethiopia.
Follow up for 180-days for objective 1 and continous follow-up for objective 2. Comparison With matched Controls. Outcome measures: Mortality, complications (heart failure, arrhythmias, thrombosis, bleedings, stroke, infections)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cases | RHD patients undergoing Cardiac surgery at Addis Abeba University Hospital |
| |
| RHD controls | RHD patients not offered Cardiac surgery | ||
| Anticoagulation controls | Norwegian patients on anticoagulant therapy due to mechanical valve implants |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cardiac surgery | Procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| Short term outcome | Freedom from Death or complication | 180 days |
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| Measure | Description | Time Frame |
|---|---|---|
| Time in therapeutic INR | Time in therapeutic window (anticoagulation) | 2 years |
| Mitral valve area by Doppler | Influence of concomitant pathology for Echocardiographic assessment of mitral stenosis |
Inclusion Criteria:
Exclusion Criteria:
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Cases: Patients offered Cardiac surgery due to indication symptomatic rheumatic heart disease
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Haavard Dalen, MD, PhD | Contact | 74098206 | 0047 | havard.dalen@ntnu.no |
| Rune Haaverstad, MD, PhD | Contact | 55 97 22 20 | 0047 | rune.haaverstad@helse-bergen.no |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Black Lion University Hospital | Recruiting | Addis Ababa | Ethiopia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34376574 | Result | Hauge SW, Dalen H, Estensen ME, Persson RM, Abebe S, Mekonnen D, Nega B, Solholm A, Farstad M, Bogale N, Graven T, Nielssen NE, Brekke HK, Vikenes K, Haaverstad R. Short-term outcome after open-heart surgery for severe chronic rheumatic heart disease in a low-income country, with comparison with an historical control group: an observational study. Open Heart. 2021 Aug;8(2):e001706. doi: 10.1136/openhrt-2021-001706. |
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No written plan. Under discussion.
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Blood samples
| 14 days |
| Mitral phenotype in rheumatic heart disease | Influence of mitral valve phenotype with cardiac morphology and complications in untreated rheumatic heart disease patients | 0 days |
| Haukeland University Hospital | Recruiting | Bergen | Norway |
|
| Oslo University Hospital | Recruiting | Oslo | Norway |
|
| St. Olav University Hospital | Recruiting | Trondheim | 7491 | Norway |
|
| ID | Term |
|---|---|
| D012214 | Rheumatic Heart Disease |
| ID | Term |
|---|---|
| D012213 | Rheumatic Fever |
| D013290 | Streptococcal Infections |
| D016908 | Gram-Positive Bacterial Infections |
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D006348 | Cardiac Surgical Procedures |
| ID | Term |
|---|---|
| D013504 | Cardiovascular Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
| D019616 | Thoracic Surgical Procedures |
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