70ml of Peptide Supplement (670mg) to be consumed daily in the morning before meals for 2 years.

70ml of placebo (caesinate) to be consumed daily in the morning before meals for 2 years.

Change from baseline in Alzheimer's Disease Composite Score (ADCOMS). ADCOMS composite score is a weighted linear combination of the 12 items in the Wold's partial least squares (PLS) model. Composite scores range from 0.0 to a maximum of 1.97, where higher values indicate worse performance.

Change from baseline in blood myeloperoxidase (MPO) Higher levels of MPO indicate worse oxidative stress status

Change from baseline in inflammation, measured by the following blood biomarkers. Each biomarker will be evaluated individually.

1. High-sensitivity C-reactive Protein (hs-CRP)
2. Erythrocyte Sedimentation Rate (ESR)
3. Tumor necrosis factor alpha (TNFα)
4. Interleukin 6 (IL-6)

Change from baseline in fasting blood glucose level

Change from baseline in patient-reported Taiwanese Depression Questionnaire (TQD) scores.

TDQ scores range from 0 to 54, with the higher score indicating the greater depression state.

Change from baseline in Short Form-36 (SF-36) Component and Scale Scores. Each scale is directly transformed into a 0 - 100 scale on the assumption that each question carries equal weight. Lower score indicates more disability/worse health status.

Change from baseline in Athens Insomnia Scale Score. A composite score which ranges from 0-24 will be evaluated. Higher score stands for greater severity of insomnia.

Number and incidence of infections occurring during the study period according to a self-reported infection survey

Mean values of cerebral blood flow measured with sonography

Change from baseline in systolic and diastolic blood pressure