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The purpose of the study is to examine the effect of two different high intensity interval training (HIIT) prescription approaches on improving fitness, heart function, and the ability of the body's muscles to receive oxygen.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Standard-care interval-training group | Active Comparator | Subjects will complete a standard interval-training program that remains constant for the entire 12 weeks of cardiac rehabilitation. |
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| Progressive interval-training group | Experimental | Subjects will complete an interval-training program during which the number of intervals and the duration of each interval are changed across the 12-week cardiac rehabilitation program. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Progressive High Intensity Interval Training (PRO-HIIT) | Other | Individual exercise training sessions, involving two weeks of moderate intensity continuous exercise and 10 weeks of interval exercise training. This protocol involves progression of training of 3 stages: 1) six high-intensity intervals (at an RPE of 15-18) of 1-min separated by five low-intensity intervals of 2-min; 2) three high-intensity intervals of 2-min separated by two low-intensity intervals of 4-min, and a further 2-min of low intensity following the last interval before cool-down; and 3) three high-intensity intervals of 3-min separated by two low-intensity intervals of 3-min, and a further 1-min of low intensity following last interval before cool-down. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in cardiorepiratory fitness | Measure as peak oxygen consumption (VO2 peak) | Pre and post study completion, approximately 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change in oxygen uptake response time | Measured as exponential time-constant of pulmonary oxygen uptake at exercise onset | Weekly, over 12 weeks |
| Change in locomotor muscle oxygenation | Measured as tissue oxygen saturation by near-infrared spectroscopy (NIRS) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Amanda R Bonikowske, PhD | Mayo Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo Clinic in Rochester | Rochester | Minnesota | 55905 | United States |
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| Label | URL |
|---|---|
| Mayo Clinic Clinical Trials | View source |
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| Constant High Intensity Interval Training (CON-HIIT) | Other | Individual exercise training sessions, involving two weeks of moderate intensity continuous exercise and 10 weeks of interval exercise training. This protocol involves a constant protocol of training, including six high-intensity intervals (at an RPE of 15-18) of 1-min separated by five low-intensity intervals of 2-min. |
|
| Pre and post study completion, 12 weeks |
| Change in metaboreflex stimulation | Measured as changes in blood pressure during recovery from exercise | Pre and post study completion, 12 weeks |
| Changes in mechanoreflex stimulation and sensitization | Measured as changes in blood pressure during recovery from exercise | Pre and post study completion, 12 weeks |
| Change in cardiac function | Measured as global longitudinal strain by echocardiography at rest and during sub-maximal exercise | Pre and post study completion, 12 weeks |
| Change in body composition | Measured as fat mass by dual-energy x-ray absorptiometry | Pre and post study completion, 12 weeks |
| Change in blood pressure | Measured as resting and mean 24-hr blood pressures by ambulatory blood pressure monitor | Pre and post study completion, 12 weeks |
| Change in blood lipids | Measured as total-cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides | Pre and post study completion, 12 weeks |
| Change in physical activity | Measured as minutes spent in moderate-vigorous physical activity, by accelerometer monitor | Pre and post study completion, 12 weeks |