Bone Toxicity Following Pelvic Radiotherapy

Bone Toxicity Following Pelvic Radiotherapy: A Prospective Randomised Controlled Feasibility Study Evaluating a Musculoskeletal Health Package in Women With Gynaecological Cancers Undergoing Pelvic Radiotherapy

A randomised controlled clinical feasibility trial to determine the feasibility and acceptability of a "musculoskeletal health package (MHP)" intervention in women undergoing pelvic radiotherapy for gynaecological malignancies and inform power calculations for a definitive trial.

Inclusion Criteria:

• age over 18 years
• histologically confirmed uterine or cervix cancer
• patients undergoing potentially curative/adjuvant radiotherapy
• ability to give informed consent to participate

Exclusion Criteria:

• age less than 18 years or greater than 85 years
• patients with pre-existing bone conditions such as: osteoporosis treated with bisphosphonates in the previous 5 years/fibrous dysplasia/osteogenesis imperfecta or other metabolic bone condition
• inability to give informed consent to participate
• home address outside Greater Manchester
• contraindication or intolerance of Magnetic Resonance scanning