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Total hip arthroplasty (THA) is one of the main elective orthopedic surgery. Recent studies have proven that patients undergoing an elective THA who are part of a fast track surgery program including an opioid free anesthesia (OFA) presented a decrease of mortality and a reduced in-hospital length of stay. Based on the anatomical knowledges, the Quadratus Lumborum Block seems to be an interesting locoregional technique for patients undergoing THA. So far, there is no recommanded locoregional aesthesia in this indication. The investigators hypothezised that QLB would give an efficient analgesia in the 24h following a THA.
Therefor, the study performed a prospective, randomized, double blind trial in the Nice Universitary hospital of Pasteur 2 and in Arnault Tzanck Institute among all patients who underwent THA, comparing a QLB using ropivacaïne 2mg/ml 20ml vs isotonic saline solution 20 ml.The main end-point is the decrease opiod consumption in the 24h following THA.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Drug Ropivacaïne 2 mg/ml | Experimental | Realization of the quadratum lumborum block type 3, ultrasounds' guided by the injection of 20 ml of ropivacaïne 2 mg/ml |
|
| NACL | Placebo Comparator | Realization of the quadratum lumborum block type 3, ultrasounds' guided by the injection of 20 ml of NACL |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ropivacaine injection | Drug | Realization of the quadratum lumborum block type 3, ultrasounds' guided by the injection of 20 ml of ropivacaïne 2 mg/ml |
|
| Measure | Description | Time Frame |
|---|---|---|
| Opoïd consumption | The main end point of this study is the decrease of opiod consumption in the 24h following THA. | At 24 Hours |
| Measure | Description | Time Frame |
|---|---|---|
| morphine equivalent dose | following surgery at rest and in motion | At 48 Hours |
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Inclusion Criteria:
• All adult patients with unilateral programmed total hip prosthesis surgery are included in the absence of inclusion criteria.
Exclusion Criteria:
chronic opiod consumption
pregnancy
mental disorder that prevents the usage of the numeric analog scale
Contra indications of the realization of QLB
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| Name | Affiliation | Role |
|---|---|---|
| Rozier Romain | Anesthésie Réanimation - CHU de Nice | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de nice - Anesthésie Réanimation | Nice | Alpes-Maritimes | 06001 | France | ||
| Institut Arnaut Tzanck |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39929638 | Result | Rozier R, Loiseleur A, Ciais C, Moulin O, Alais B, Marguerite K, Badia E, Tran L, Balbo J, Maurice-Szamburski A. Anterior quadratus lumborum block in total hip arthroplasty: a two-center, randomized, placebo-controlled trial showing no additional benefit over multimodal analgesia. Reg Anesth Pain Med. 2026 May 5;51(5):491-497. doi: 10.1136/rapm-2024-106247. |
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| ID | Term |
|---|---|
| D000077212 | Ropivacaine |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
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| NACL | Other | Realization of the quadratum lumborum block type 3, ultrasounds' guided by the injection of 20 ml of NACL |
|
| Nice |
| Alpes-Maritimes |
| 06700 |
| France |
| D000588 |
| Amines |