Effect of Heat Stress on Global LV Function in Anesthetized Humans

Effect of Heat Stress on Global LV Function in Anesthetized Humans

Recent data suggests that increased temperature improves inotropic function during systole and may improve diastolic function in healthy humans at rest, despite a reduction in left ventricular volume at end diastole. The effect of heat stress has not been reported in patients receiving general anesthesia and the impact of general anesthesia on these findings is not known. Trans-esophageal echocardiography will be used to measure parameters important to both systolic and diastolic function at temperature intervals of 1°C in patients undergoing "Heated Intraoperative Peritoneal Chemotherapy" (HIPEC.) That general anesthesia will not alter the cardiovascular effects of increased temperature that has been reported in healthy, un-anesthetized humans is the hypothesis.

Inclusion Criteria:

• any patient presenting for hyperthermic intraperitoneal chemotherapy.

Exclusion Criteria:

• Subjects less than 18 years old.
• pregnant women
• prisoners,
• institutionalized individuals
• Any patient with known contraindication to Transesophageal echocardiography.
• Patients with known cardiac dysfunction prior to screening will be excluded.