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This study aims to evaluate the usefulness of blood viscosity as a prognostic factor in patients with acute pancreatitis. The study design is a single-arm prospective cohort observational study. Blood biomarkers including blood viscosity, C-reactive protein, hematocrit, and phosphate are measured and the correlation with the severity of acute pancreatitis will be analyzed.
Several scoring systems are used to evaluate the prognosis of acute pancreatitis, but they are rather complicated and clinically less useful. Blood viscosity is associated with hematocrit and inflammatory factors known to be related to the prognosis of acute pancreatitis, and our group's previous study which is not yet published showed that blood viscosity better predicts severe acute pancreatitis than other single factors such as C-reative protein. Therefore, this study aims to prospectively evaluate the usefulness of blood viscosity as a prognostic factor for acute pancreatitis. During the study period, the study is conducted on patients with acute pancreatitis between the ages of 19 and 70, and patients with acute pancreatitis after ERCP are excluded. Blood viscosities at initial and 24 hours after hospitalization, and serum phosphate, which have shown potential as a predictor of severity in post-ERCP pancreatitis in previous studies are measured. The association of these blood biomarkers with the severity of acute pancreatitis will be analyzed and compared with hematocrit, C-reactive protein, etc., which are known as a single prognostic predictor of acute pancreatitis.
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| Measure | Description | Time Frame |
|---|---|---|
| Prediction of severity of acute pancreatitis using initial blood viscosity | Evaluate initial blood viscosity as a predictor of the severity of acute pancreatitis | 48hours after admission |
| Measure | Description | Time Frame |
|---|---|---|
| Prediction of severity of acute pancreatitis using blood viscosity change after 24hours | Prediction of severity of acute pancreatitis using blood viscosity change after 24hours | 24hours after admission |
| Prediction of severity of acute pancreatitis using serum phosphate |
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Inclusion Criteria:
Exclusion Criteria:
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Patients between 19 and 70 years of age with acute pancreatitis, excluding post-ERCP pancreatitis.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Young Hoon Choi, MD, MS | Contact | 82-2-2258-6020 | crzyzs@naver.com | |
| In Seok Lee, MD, PhD | Contact | 82-2-2258-6022 | isle@catholic.ac.kr |
| Name | Affiliation | Role |
|---|---|---|
| In Seok Lee, MD, PhD | Seoul St. Mary's Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul St. Mary's hospital | Recruiting | Seoul | 06591 | South Korea |
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| ID | Term |
|---|---|
| D010195 | Pancreatitis |
| ID | Term |
|---|---|
| D010182 | Pancreatic Diseases |
| D004066 | Digestive System Diseases |
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Prediction of severity of acute pancreatitis using serum phosphate |
| 48hours after admission |