Immunological Response After Shrimp Oral Immunotherapy Treatment

Immunological Response After Shrimp Oral Immunotherapy Treatment

Oral immunotherapy is effective in desensitized food allergy. Shrimp allergy is increasing in Thailand. So the purpose of our study is to determine level of specific immunoglobulin E antibodies to shrimp, Immunoglobulin G4 and immunoblot analysis in shrimp allergy patients after shrimp oral immunotherapy.

All subject in this study were sensitized to shrimp. All patient was clinically evaluated, with focus on shrimp allergy by medical history, medical examination and gold standard oral food challenge test. Compare oral immunotherapy to shrimp and shrimp avoidance. Blood sample was taken for baseline determination of immunoglobulin E antibodies to shrimp. The primary outcome was the specific immunoglobulin E antibodies to shrimp,Immunoglobulin G4 and immunoblot analysis in case that oral immunotherapy.

Inclusion Criteria:

• Age 12 - 40 years old
• History of Immunoglobulin E-mediated shrimp allergy > 3 episode/year or disturb quality of life
• Positive oral food challenge test for shrimp

Exclusion Criteria:

• History of shrimp anaphylaxis (include cardiovascular or neurological symptoms)
• Shellfish dependent exercise induced anaphylaxis
• History of cardiovascular disease, uncontrolled asthma, severe atopic dermatitis
• History of Beta-blocker, Angiotensin-converting enzyme inhibitor, Angiotensin receptor blocker, Calcium channel blocker