Microneedles for Diagnosis of LTBI

Pilot Study for Development of Microneedles for Diagnosis of Latent Tuberculosis Infection

This study will evaluate new technique, microneedle, to detect latent tuberculosis (TB) in healthy volunteers

The cross-sectional study to investigate the effect of microneedle formulations and lengths of Tuberculin PPD microneedles on the delayed-type hypersensitivity response in healthy volunteers.

Inclusion Criteria:

1. Sex : Male and Female
2. Age : 20-60 years
3. TB contacts or those at risk of TB e.g. health-care workers
4. HIV-negative healthy individuals

Exclusion Criteria:

1. Presence of an acute infection, as determined by investigators
2. Receiving immunosuppression drugs e.g. steroids
3. Having autoimmune diseases e.g. SLE (Systemic Lupus Erythematous)
4. Being pregnant or breastfeeding