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| Name | Class |
|---|---|
| Hospital Centre Biel/Bienne | OTHER |
| Luzerner Kantonsspital | OTHER |
| Kantonsspital Aarau | OTHER |
| Kantonsspital Liestal |
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The complication rate in colorectal surgery is high and shows a large variance depending on the patient and the treating surgeon. The primary aim of the presented study is to evaluate the introduction of a colorectal bundle to reduce the complication rate in left sided colorectal resections. The colorectal bundle is a catalog of measures consisting of several items These are for example preoperative risk stratification, antibiotic and mechanical bowel preparation and preoperative showering. The primary endpoint will be the complication rate measured as the comprehensive clinical index (CCI) within 30 days. Investigators will include patients that undergo elective or emergency left sided colorectal surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control Arm | No Intervention | Patients are treated according to current local standards | |
| Colorectal Bundle Arm | Experimental | Patients are treated according to the colorectal bundle |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Colorectal Bundle | Procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| Comprehensive complication index | The primary endpoint is the comprehensive complication index (CCI) at 30 days after the index procedure, a continuous scale to measure surgical morbidity that has been developed on the basis of the Clavien Dindo Classification for surgical complications and summarizes and weighs all postoperative complications to a scale from 0 (no complications) to 100 (death of the patient) . | 30 days |
| Measure | Description | Time Frame |
|---|---|---|
| Surgical side infections | Rate of surgical side infections within 30 days | 30 days |
| Number of patients who died within 30 days | Postoperative mortality within 30 days |
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Inclusion Criteria:
Exclusion Criteria:
Exclusion criteria for an antibiotic decontamination subgroup:
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| Name | Affiliation | Role |
|---|---|---|
| Marco von Strauss und Tourney, PD Dr. | Clarunis - Universitäres Bauchzentrum Basel | Principal Investigator |
| Markus Zuber, Prof. Dr. | Clarunis - Universitäres Bauchzentrum Basel | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kantonsspital Baselland | Liestal | Basel-Landschaft | 4410 | Switzerland | ||
| Lantonsspital Aarau |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31293019 | Background | Bergvall M, Skullman S, Kodeda K, Larsson PA. Better survival for patients with colon cancer operated on by specialized colorectal surgeons - a nationwide population-based study in Sweden 2007-2010. Colorectal Dis. 2019 Dec;21(12):1379-1386. doi: 10.1111/codi.14760. Epub 2019 Jul 30. | |
| 30255647 | Background |
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| OTHER |
| Spital Limmattal Schlieren | OTHER |
| Kantonsspital Olten | OTHER |
| Clarunis - Universitäres Bauchzentrum Basel | OTHER |
Prospective, randomised, multicenter trial
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|
| 30 days |
| Hospital length of stay | Length of hospital stay in days | immediately after discharge |
| Contribution margin | Measured as the difference between allocated costs and billed and payed income for a particular case | immediately after discharge |
| Rate of anastomotic leakage | Any radiologically or clinically diagnosed anastomotic leakage | 30 days |
| Aarau |
| Canton of Aargau |
| 5001 |
| Switzerland |
| Clarunis-universitäres Bauchzentrum | Basel | Canton of Basel-City | 4031 | Switzerland |
| Spitalzentrum Biel | Biel/Bienne | Canton of Bern | 2501 | Switzerland |
| Kantonsspital Luzern | Lucerne | Canton of Lucerne | 6004 | Switzerland |
| Kantonsspital Olten | Olten | Canton of Solothurn | 4600 | Switzerland |
| Spital Limmattal | Schlieren | Canton of Zurich | 8652 | Switzerland |
| 2017 European Society of Coloproctology (ESCP) collaborating group. Safety of primary anastomosis following emergency left sided colorectal resection: an international, multi-centre prospective audit. Colorectal Dis. 2018 Sep;20 Suppl 6:47-57. doi: 10.1111/codi.14373. |
| 30255645 | Background | 2017 European Society of Coloproctology (ESCP) Collaborating Group. The 2017 European Society of Coloproctology (ESCP) international snapshot audit of left colon, sigmoid and rectal resections - Executive Summary. Colorectal Dis. 2018 Sep;20 Suppl 6:13-14. doi: 10.1111/codi.14391. No abstract available. |
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| 41772236 | Derived | Wiesler B, Worni M, Studer P, Gass JM, Metzger J, Hartel M, Nebiker C, Rosenberg R, Galli R, Eisner L, Andreou C, Zingg U, Stimpfle D, Viehl CT, Muller A, Muller B, Denhaerynck K, Hall P, Gallagher C, Karunaratne P, Lilley C, Zuber M, Paterson H, von Strauss Und Torney M. How Is Colorectal Cancer Care Impacted by Global Crisis in Contrasting Healthcare Systems?-A Descriptive Study From Scotland and Switzerland During the COVID-19 Pandemic. World J Surg. 2026 Apr;50(4):818-828. doi: 10.1002/wjs.70294. Epub 2026 Mar 2. |
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| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| D057868 | Anastomotic Leak |
| ID | Term |
|---|---|
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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