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| Name | Class |
|---|---|
| Health Sciences Centre Foundation, Manitoba | OTHER |
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Intraspinal pressure monitoring has been advanced as a potential technique for evaluating spinal cord perfusion after traumatic spinal cord injury. In this study, the investigators aim to validate the technique for insertion of a fiberoptic pressure monitoring device in the subarachnoid space at the site of injury for measurement of intraspinal pressure and spinal cord perfusion pressure. The primary objective of this study is to validate the methodology of invasive intraspinal pressure monitoring to derive parameters for optimal spinal cord perfusion pressure, spinal cord reserve capacity and spinal reactivity index using data obtained during the patient's stay in the intensive care unit.
Secondary objectives of this study will be to a) evaluate the safety of invasive intraspinal pressure monitoring, b) prospectively evaluate the overall relationship between spinal cord perfusion pressure and functional outcomes in patients with acute traumatic spinal cord injury and c) evaluate the relationship between spinal cord perfusion pressure, motor evoked potentials and functional outcomes after incomplete spinal cord injury.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intraspinal Pressure Monitoring | Experimental | A fiberoptic pressure monitoring device will be placed into the subarachnoid space at the site of traumatic spinal cord injury |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Insertion of Intraspinal pressure monitor | Procedure | A fiberoptic pressure monitoring wire will be placed into the subarachnoid space at the site of traumatic spinal cord injury |
|
| Measure | Description | Time Frame |
|---|---|---|
| Derivation of parameters for optimal spinal cord perfusion pressure using intraspinal pressure data | Derivation of parameters for optimal spinal cord perfusion pressure. | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of the accuracy of probe placement in relation to the site of injury | 1 year | |
| Measure the correlation between spinal cord perfusion pressure and the American Spinal Injury Association (ASIA) Impairment scale, Quality of Life Index and Spinal Cord Independence Measure score. |
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Inclusion Criteria:
• patients with acute traumatic spinal cord injury ASIA A, B or C
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Perry Dhaliwal, MD MPH | Contact | 2047877227 | pdhaliwal@exchange.hsc.mb.ca | |
| Frederick Zeiler, MD PhD | Contact | 2047877227 | frederick.zeiler@umanitoba.ca |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Health Sciences Centre | Recruiting | Winnipeg | Manitoba | R3A1R9 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36126069 | Derived | Dhaliwal P, Wilkinson M, Zeiler FA. The Winnipeg Intraspinal Pressure Monitoring Study (WISP): A protocol for validation of fiberoptic pressure monitoring for acute traumatic spinal cord injury. PLoS One. 2022 Sep 20;17(9):e0263499. doi: 10.1371/journal.pone.0263499. eCollection 2022. |
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| ID | Term |
|---|---|
| D013119 | Spinal Cord Injuries |
| D013124 | Spinal Injuries |
| ID | Term |
|---|---|
| D013118 | Spinal Cord Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020196 | Trauma, Nervous System |
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| 1 year |
| Record rates of adverse events in patients having insertion of intraspinal pressure monitor | Measure infection rates, rates of pseudomeningoceles, neurological injury, probe dislodgment, meningitis and or subdural hematoma at injury site. | 1 year |
| D014947 | Wounds and Injuries |
| D019567 | Back Injuries |