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This study aim to evaluate the clinical efficacy and safety after laparoscopic sleeve gastrectomy in patients with obesity. 300 patients with obesity and 49 healthy individuals with normal BMI were enrolled.
This study aim to evaluate the clinical efficacy and safety after laparoscopic sleeve gastrectomy in patients with obesity. 300 patients with obesity and 49 healthy individuals with normal BMI were enrolled.
All patients with obesity underwent LSG. A multidisciplinary team evaluated participants with obesity at baseline, 1, 3, 6, 12, 24, and 36 months after LSG. Anthropometrics, Metabolic indicators, sex hormones, menstruation，glucose-lipid metabolic markers, and hepatic steatosis assessed by FibroScan(CAP value and E value) were measured baseline and postoperative.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| LSG in obese | Patients with obesity underwent LSG. Divided into simple obese patients (without complications) and obese patients with complications |
| |
| Control group | healthy individuals with normal BMI |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Laparoscopic sleeve gastrectomy | Procedure | bariatric surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| Hepatic steatosis | hepatic steatosis assessed by FibroScan(CAP value and E value) | 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| BMI | BMI=weight(kg)/height(m)^2 | 3 years |
| Menstrual cycles | the total number of menstrual periods in the last year | 3 years |
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Inclusion Criteria:
1) age ranged from 16~65 years old, 2) BMI over 37.5 kg/m2, or BMI over 32.5 kg/m2 with diabetes which meets the recommended cutoff for bariatric surgery of the Guidelines for surgical treatment of obesity accompanied with or without type 2 diabetes in China. -
Exclusion Criteria:
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300 subjects with obesity or overweight
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42029999 | Derived | Guo J, Tian P, Yu J, Lu G, Mutailipu K, Wen X, Wang X, You H, Zhu C, Lu L, Wang Y, Qu S, Chen H, Zhuang Y, Bu L. Development and External Validation of a Prediction Model for Hypoxemia After Laparoscopic Sleeve Gastrectomy in Patients with Obesity: a Multicenter Retrospective Study. Obes Surg. 2026 Jun;36(6):2767-2780. doi: 10.1007/s11695-025-07961-y. Epub 2026 Apr 24. | |
| 39511506 |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D065626 | Non-alcoholic Fatty Liver Disease |
| D003924 | Diabetes Mellitus, Type 2 |
| D011085 | Polycystic Ovary Syndrome |
| D000052 | Acanthosis Nigricans |
| D033461 | Hyperuricemia |
| D006946 | Hyperinsulinism |
| D012891 | Sleep Apnea Syndromes |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| Waist/hip Ratio | WHR=Waist Circumference in centimeter/Hip Circumference in centimeter | 3 years |
| TT | total testosterone in nmol/L | 3 years |
| FBG | fasting blood-glucose in mmol/L | 3 years |
| PBG | postprandial blood-glucose in mmol/L | 3 years |
| FINS | fasting serum insulin in mU/L | 3 years |
| PINS | postprandial insulin in mU/L | 3 years |
| ALT | alanine aminotransferase in U/L | 3 years |
| AST | aspartate aminotransferase in U/L | 3 years |
| UA | Uric acid in umol/L | 3 years |
| HOMA-IR | Homeostatic model assessment insulin resistance index=FBG*FINS/22.5 | 3 years |
| HbA1c (%)， | Glycated hemoglobin | 3 years |
| SHBG | sex hormone-binding globulin in nmol/L | 3 years |
| FT | free testosterone (nmol/L) | 3 years |
| DHEAS | Dehydroepiandrosterone Sulfate (ug/dl) | 3 years |
| LDL-C | low-density lipoprotein cholesterol in mmol/L、 | 3 years |
| HDL-C | Hight-density lipoprotein cholesterol in mmol/L、 | 3 years |
| Fertility | sexual function, fertility | 3 years |
| Derived |
| Wang X, Fang Y, Huang X, Du L, Ren H, Sheng C, Yang P, Huang Y, Qu S. Relationship of serum iron and thyroid hormone in obesity and after laparoscopic sleeve gastrectomy. BMC Endocr Disord. 2024 Nov 7;24(1):240. doi: 10.1186/s12902-024-01753-8. |
| 35399676 | Derived | Ma B, Yang P, Gao J, Du L, Sheng C, Usman T, Wang X, Qu S. Relationship of Vitamin A and Thyroid Function in Individuals With Obesity and After Laparoscopic Sleeve Gastrectomy. Front Nutr. 2022 Mar 15;9:824193. doi: 10.3389/fnut.2022.824193. eCollection 2022. |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D005234 | Fatty Liver |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D010048 | Ovarian Cysts |
| D003560 | Cysts |
| D009369 | Neoplasms |
| D010049 | Ovarian Diseases |
| D000291 | Adnexal Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |
| D006058 | Gonadal Disorders |
| D008548 | Melanosis |
| D017495 | Hyperpigmentation |
| D010859 | Pigmentation Disorders |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D010335 | Pathologic Processes |
| D001049 | Apnea |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D020919 | Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |