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About 14 healthy participants, consume a standardized breakfast combined with either using regular or nicotine-free moist snuff. The metabolic rate is measured every hour for four hours on each occasion starting in the morning. Participants are also randomized to get red wine or non-alcoholic red wine to the meal.
About 14 healthy participants, consume a standardized breakfast combined with either using regular or nicotine-free moist snuff. The metabolic rate is measured measured before the meal and then every hour for a total of four hours on each occasion that starts in the morning. Participants are also randomized to get red wine or non-alcoholic red wine to the meal. Since there are four possible combinations of the wine and the snuff, all participants do the test on four occasions. Except for metabolic rate we will also analyze hormone responses regarding appetite or hunger.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| red wine and snuff | Active Comparator | regular red wine and moist snuff |
|
| red wine and nicotine-free snuff | Active Comparator | regular red wine and nicotine-free snuff |
|
| non alcoholic red wine and regular moist snuff | Active Comparator | non alcoholic red wine and regular moist snuff with nicotine |
|
| non-alcoholic red wine and nicotine-free snuff | Placebo Comparator | Non-alcoholic red wine and nicotine-free snuff |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Wine with or without alcohol and snuff with or without nicotine | Other | Two by two factorial of wine and snuff with meals |
|
| Measure | Description | Time Frame |
|---|---|---|
| level of metabolic rate | Measurement of metabolic rate by registration of CO2 in breath and the oxygen uptake | 4 hours |
| Measure | Description | Time Frame |
|---|---|---|
| sense of appetite | determination of the hormones ghrelin and GLP-1 in serum | 4 hours |
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Inclusion Criteria: No significant disease -
Exclusion Criteria: known illnesses, thyroid disease, need to take prednisolone, psychiatric disease,inability to understand Swedish
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Medicine and Health Sciences | Recruiting | Linköping | Sverige | 60580 | Sweden |
There are no such plans
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| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D014920 | Wine |
| D000431 | Ethanol |
| D014030 | Tobacco, Smokeless |
| D009538 | Nicotine |
| ID | Term |
|---|---|
| D000434 | Alcoholic Beverages |
| D001628 | Beverages |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
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We use non-alcoholic or alcohol containing wine and regular or nicotine free snuff
| D000088082 |
| Fermented Beverages |
| D000074421 | Fermented Foods |
| D019602 | Food and Beverages |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D062789 | Tobacco Products |
| D000074602 | Smoking Devices |
| D008420 | Manufactured Materials |
| D013676 | Technology, Industry, and Agriculture |
| D012991 | Solanaceous Alkaloids |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D011725 | Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |