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FIBRACEP is an onion based fiber that has demonstrated in vitro and in animal models the capacity to increase HDL cholesterol levels as well to improve other lipid profile species. This intervention aims to demonstrate FIBRACEP's blood lipid profile improvement effect. For that purpose, hypercholesterolemic subjects will be recruited and given a daily dose of 7 g of FIBRACEP for two months. Changes in blood lipid profile will be the end-point of the study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Insoluble Fibre | Active Comparator | Cookies with insoluble fibre (wheat bran) |
|
| Soluble Fibre | Active Comparator | Cookies with soluble fibre (Psyllium plantago) |
|
| FIBRACEP | Experimental | Cookies with FIBRACEP |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| FIBRACEP | Dietary Supplement | A total intake of 7 g/day of FIBRACEP (provided in 6 cookies of 15 g/each) during two months |
|
| Measure | Description | Time Frame |
|---|---|---|
| Blood HDL-cholesterol | Cholesterol content in HDL lipoproteins determined by nuclear magnetic resonance | 2 months |
| Measure | Description | Time Frame |
|---|---|---|
| Blood lipid profile | Cholesterol content in LDL, VLDL (Very low-density lipoproteins) density and IDL lipoproteins determined by NMR | 2 months |
| Blood lipoprotein number | Number of lipoproteins determined by nuclear magnetic resonance |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| José Serrano Casasola | Lleida | 25198 | Spain |
By request to Principal Investigator
January 2021, for 2 years.
By e-mail to Principal Investigator, who will decide to share the data if fulfill research purposes.
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| ID | Term |
|---|---|
| D006937 | Hypercholesterolemia |
| ID | Term |
|---|---|
| D006949 | Hyperlipidemias |
| D050171 | Dyslipidemias |
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| INSOLUBLE | Dietary Supplement | A total intake of 7 g/day of wheat bran (provided in 6 cookies of 15 g/each) during two months |
|
|
| SOLUBLE | Dietary Supplement | A total intake of 7 g/day of psyllium plantago (provided in 6 cookies of 15g/each) during two months |
|
|
| 2 months |
| Blood lipoprotein size | The average size of each lipoprotein specie (HDL, LDL, VLDL, IDL) determined by nuclear magnetic resonance | 2 months |
| D009750 |
| Nutritional and Metabolic Diseases |