Aortic dissection is a deadly and dangerous disease. About 28% of patients with ascending aortic dissection can't tolerate open surgical trauma caused by thoracotomy and cardiopulmonary bypass, and the prognosis is poor. Minimally invasive endovascular treatment has been applied in the treatment of descending aortic dissection. However, due to the special anatomical structure and high speed /pressure blood flow, the treatment of ascending aorta dissection has become an international difficulty.

This study was designed combination of retrospective and prospective methods, and focused on distal false lumen Aneurysmal Expansion of Aortic Dissection (DAEAD) . To formulate clinical data for the risk assessment of DAEAD, and best intracavitary treatment or long-term efficacy evaluation, we combined the results of genetic testing, evaluating the missense mutation, computer simulation of blood flow dynamics analysis, and clinical imaging analysis.

Inclusion Criteria:

• Aortic dissection diagnosed by CTA;
• With indications for endovascular treatment
• The luminal graft anchor is required to be located in the ascending aorta.

Exclusion Criteria:

• Import difficult, such as external iliac artery diameter is less than 6 mm bilateral iliac, artery stenosis distortions;
• Patients with severe comorbidities, such as severe myocardial insufficient blood supply, heart failure, arrhythmia, severe renal dysfunction, and severe blood coagulation dysfunction;
• Patients with malignant tumor, or other serious illness, life expectancy of less than 1 year；
• Puncture local infection and high fever;⑤ within 1 month of the large area;
• Contrast media in patients with cerebrovascular accident or digestive tract hemorrhage patients with allergies;
• Aortic ulcer or aortic wall hematoma and other atypical dissection.

This clinical trial included a prospective study of patients admitted to the hospital with aortic dissection between October 2020 and September 2023 who were treated with an endoluminal graft after exclusion of surgical contraindications.