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Describe the efficacy of the use of topical besifloxacin in reducing the conjunctival microbiota as a prophylactic measure in patients scheduled for cataract surgery.
Randomized double-blind clinical trial. Study carried out in a single center between January and April 2017. 60 eyes were included that were randomly divided in a 1: 1 ratio into two groups. The first group received placebo (hydroxypropylmethylcellulose drops) while the second group received 0.6% besifloxacin drops four times a day for 3 days. All of them had a conjunctival cul-de-sac culture before and after treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Besifloxacin | Active Comparator | 1 DROP 4 TIMES A DAY FOR 3 DAYS PRIOR SURGERY |
|
| Hydroxypropyl methylcellulose | Placebo Comparator | 1 DROP 4 TIMES A DAY FOR 3 DAYS PRIOR SURGERY |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Besifloxacin Ophthalmic | Drug | Prophylaxis for endophthalmitis |
|
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of positive cultures before and after treatment in each arm | A conjunctival cul-de-sac sample will be taken before starting treatment and before surgery, which will be cultured on 3 different media types: Blood, Chocolate and Sabouraud agar. | Through study completion, an average of 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Eduardo Chavez-Mondragon, MD | Instutute of Ophthalmology "Conde de Valenciana" | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of Ophthalmology, Conde de Valenciana Foundation | Mexico City | Mexico City | 06800 | Mexico |
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| Hydroxypropyl Methylcellulose Ophthalmic Ophthalmic Solution | Drug | Placebo |
|
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