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| Name | Class |
|---|---|
| Center for Clinical Research Dalarna, Sweden | OTHER |
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The Corona virus disease 2019 (COVID-19) pandemic is currently involving all parts of the world. Several risk factors for critical illness and death from the disease have been proposed. However, it is still unclear if the observed associations between different comorbidities and chronic medications and severe COVID-19 disease and mortality is different from associations between the same factors and other severe diseases requiring intensive care unit (ICU) -care. This is important since some of the observed risk factors are very common in the aged who, by age alone, are more prone to a more severe course of any disease. By combining several registries, this study will compare, on several comorbidities such as hypertension and diabetes , the first 2000 cases of COVID-19 patients receiving critical care in Sweden to a Swedish sepsis-cohort and a Swedish adult respiratory distress syndrome (ARDS) -cohort.
The Corona virus disease 2019 (COVID-19) pandemic is currently involving all parts of the world. Several risk factors for critical illness and death from the disease have been proposed. However, it is still unclear if the observed associations between different comorbidities and chronic medications and severe COVID-19 disease and mortality is different from associations between the same factors and other severe diseases requiring ICU-care. This is important since some of the observed risk factors are very common in the aged who, by age alone, are more prone to a more severe course of any disease. By combining several registries, this study will compare, on several comorbidities such as hypertension and diabetes , the first 2000 cases of COVID-19 patients receiving critical care in Sweden to a Swedish sepsis-cohort and a Swedish ARDS-cohort.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| COVID-19 critical care patients | All patients who have received intensive care with COVID-19 in Sweden until May 27, 2020. Patients are identified in the Swedish Intensive care registry, to which all Swedish intensive care units (ICU) are reporting all intensive care patients. |
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| Sepsis critical care patients | All patients who have received intensive care with severe sepsis or septic shock in Sweden between 2011 and 2016. Patients are identified in the Swedish Intensive care registry, to which all Swedish intensive care units (ICU) are reporting all intensive care patients. |
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| ARDS critical care patients | All patients who have received intensive care with ARDS in Sweden between 2011 and 2016. Patients are identified in the Swedish Intensive care registry, to which all Swedish intensive care units (ICU) are reporting all intensive care patients. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention, observational study | Other |
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| Measure | Description | Time Frame |
|---|---|---|
| Risk factors of ICU care COVID-19/Sepsis | In a binary logistics model with the outcome Sepsis or COVID-19 the OR for several comorbidities are determined. | Five years preceding ICU admission to ICU admission |
| Risk factors of ICU care COVID-19/ARDS | In a binary logistics model with the outcome ARDS or COVID-19 the OR for several comorbidities are determined. | Five years preceding ICU admission to ICU admission |
| Risk factors of ICU mortality COVID-19/Sepsis | In a Cox proportional hazards model with the outcome ICU-mortality the hazard ratio (HR) for the interaction between several comorbidities and a binary variable COVID-19/Sepsis are determined. | Five years preceding ICU admission to ICU discharge |
| Risk factors of ICU mortality COVID-19/ARDS | In a Cox proportional hazards model with the outcome ICU-mortality the HR for the interaction between several comorbidities and a binary variable COVID-19/ARDS are determined. | Five years preceding ICU admission to ICU discharge |
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Inclusion Criteria:
° Individual registered in the Swedish intensive care registry (SIR) with COVID-19 Before 27 May 2020.
or
Exclusion Criteria:
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The SIR is a registry to which all Swedish intensive care units are reporting all intensive care patients. The SIR has a specific part to wich all COVID-19 related intensive care eposodes are reported. All patients, approximally 2000, who have at least one COVID-19 listing in the SIRI will be included, as cases. Two historical control populations are extracted from the SIR between 2011 and 2016. One population with all patients having had severe sepsis and one with all patients having had ARDS during ICU care.
We already have recieved all data on the studypopulation and the Control populations but will not set up the database or perform any analyses until this registration is be public.
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| Name | Affiliation | Role |
|---|---|---|
| Miklos Lipcsey, PhD | Uppsala University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Björn Ahlström | Falun | 79182 | Sweden |
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| ID | Term |
|---|---|
| D018805 | Sepsis |
| D018352 | Coronavirus Infections |
| D012128 | Respiratory Distress Syndrome |
| ID | Term |
|---|---|
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| D019370 | Observation |
| ID | Term |
|---|---|
| D008722 | Methods |
| D008919 | Investigative Techniques |
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| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D012120 | Respiration Disorders |