Efficacy of Diuretics in Kidney Disease

Efficacy of Diuretics in Kidney Disease

This study will determine the efficacy of diuretics in patients with chronic kidney disease.

Participants with chronic kidney disease will undergo two 1-week study periods (single-dose diuretic versus single-dose placebo) separated by 1-2 weeks of washout in a cross-over design. Blood and urine samples will be collected at the end of each study period to determine the effect on urine output and to assess the kidney clearance and levels of uremic solute. Participants will weigh themselves daily.

Inclusion Criteria:

• stable chronic kidney disease patients able to provide consent
• stable dialysis patients who produce urine and able to provide consent

Exclusion Criteria:

• use of antibiotics for last two months or expected antibiotic use
• recent hospitalization or other event resulting in instability of food intake