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compare the effectiveness of different doses of dexamethasone used for postoperative nausea and vomiting prophylaxis in obese patients and in normal weight patients.
compare the effectiveness of different doses of dexamethasone used for postoperative nausea and vomiting prophylaxis in obese patients.
compare the effectiveness of dexamethasone given in 4 mg and 8 mg doses in obese patients with 4 mg doses of dexamethasone in normal weight patients.
4 mg iv dexamethasone will be administered to normal weight patients at induction of anesthesia. This group will be classified as the control group. In obese patients (BMI>30 kg/m2), one group will receive 4 mg dexamethasone and other group will receive 8 mg dexamethasone at induction.
Patients will receive general anesthesia with volatile anesthetics and tramadol will be administered IV at the end of surgery.
Postoperative nausea and vomiting, postoperative pain, blood glucose, wound infection, time to oral intake, hospital stay will be compared.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control | Active Comparator | patients with BMI=18.5-24.9 kg/m2 will be received 4 mg dexamethasone at induction of anesthesia for postoperative nausea and vomiting prophylaxis. |
|
| 4 mg | Active Comparator | patients with BMI>30 kg/m2 will be received 4 mg dexamethasone at induction of anesthesia for postoperative nausea and vomiting prophylaxis. |
|
| 8 mg | Active Comparator | patients with BMI>30 kg/m2 will be received 8 mg dexamethasone at induction of anesthesia for postoperative nausea and vomiting prophylaxis. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexamethasone 4 mg IV-control | Drug | dexamethasone 4 mg will be administered at induction of anesthesia for postoperative nausea and vomiting proflaxis to normal weight patients. |
|
| Measure | Description | Time Frame |
|---|---|---|
| postoperative nausea and vomiting (PONV) | The primary outcome is the overall incidence of PONV during the first 24 h, defined as any episode of vomiting or nausea.Nausea will be measured using an 11-point verbal rating scale (VRS) running from 0 (no nausea) to 10 (the worst nausea imaginable). We will define severe PONV as nausea with a score of at least 4 on the VRS, or vomiting. | PONV scores wİll be record during the first 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| postoperative pain: 11-point VRS | Pain intensity will be measured using a simple 11-point VRS running from 0 (no pain) to 10 (unbearable pain), at rest and on mobilisation (asking the patient to cough). | Pain will be assessed during the first 24 hours |
| oral intake |
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Inclusion Criteria:
High risk patients for postoperative nausea and vomiting:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Bahar SAKIZCI UYAR | Contact | 5057000240 | drsakizciuyar@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| DiskapiYBERH | Recruiting | Ankara | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D020250 | Postoperative Nausea and Vomiting |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009325 | Nausea |
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| ID | Term |
|---|---|
| D003907 | Dexamethasone |
| ID | Term |
|---|---|
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
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| Dexamethasone 4 mg IV | Drug | dexamethasone 4 mg will be administered at induction of anesthesia for postoperative nausea and vomiting proflaxis to obese patients |
|
| Dexamethasone 8 mg IV | Drug | dexamethasone 8 mg will be administered at induction of anesthesia for postoperative nausea and vomiting proflaxis to obese patients |
|
patients will be asked first oral fluid intake time charge criteria. |
| during the first 24 hours |
| blood glucose | Fingerprick capillary blood glucose concentrations will be measured | at 6 and 10 hours after administration of dexamethasone |
| Length of Hospital Stay | the time will be recorded when patients are discharged home | during the first 24 hours |
| wound infection | Patients will be telephone on the 30th postoperative day and questioned in terms of wound infection | postoperative 30th day |
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D014839 | Vomiting |
| D000072473 |
| Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |