Use Test: Dermowas Body Lotion pH 4 vs. pH 5.8

Use Test: Dermowas Body Lotion pH 4 vs. pH 5.8

The objective of the study was to examine whether normalizing of the pH by acidification through topical treatment helps to strengthen the skin barrier, to induce epidermal differentiation and to reduce inflammation in healthy individuals.

Previous studies have shown that an emollient adjusted to pH 4 has favorable effects to the skin of aged individuals. The objective of the study was to examine whether normalizing of the pH by acidification through topical treatment helps to strengthen the skin barrier, to induce epidermal differentiation and to reduce Inflammation. The effect of a cosmetic oil-in-water (O/W) emulsion adjusted to pH 4 in comparison to the same emulsion adjusted to pH 5.8 on the integrity of the skin barrier and the mechanical stability was examined in healthy volunteers from age 18 to 75 years.

Inclusion Criteria:

• Male and female volunteers (75 % women and 25 % men)
• Aged 18 - 75 years
• Healthy skin
• Informed consent was given

Exclusion Criteria:

• Atopic diathesis, atopic dermatitis and other skin diseases with a disrupted skin barrier
• Dermatitis and other skin diseases in the test site
• Birthmarks, tattoos, scars and other abnormalities in the test site, which may influence the measurements
• Women: pregnancy and breastfeeding
• Known contact sensitization
• Severe systemic diseases
• Regular use of sauna and solarium
• Intensive UV exposure
• Topical use of drugs in the test site four weeks before and during the study
• Systemic administration of anti-inflammatory, immune-modulating and antibiotic drugs
• Previous participation in other studies within the last month before the study
• Alcohol and drug misuse
• Missing awareness and inability to follow the instructions of the study staff
• Other reasons which according to the study leader speak against the participation in the study