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The treatment before bone marrow transplantantion is initiated by chemotherapy associated or not with radiotherapy, both of which cause various side effects on the patient as symptoms that impair food intake. The nutritional status of the patient is one of the factors related to the success of the transplant, so a complete nutritional assessment before transplantation is necessary in order to identify patients at nutritional risk, nutritional disorders and to perform appropriate and early intervention to promote recovery and / or health maintenance. Will be used for nutritional assessment: arm perimeter, arm muscle area; electrical bioimpedance, phase angle, and Indirect Calorimetry, a standard method of noninvasive nutritional assessment that expresses the nutritional demand and rate of utilization of energy substrates from oxygen consumption and carbon dioxide production through the air inhaled and exhaled by the individual's lungs.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pre Transplant | All 20 patients will have the energy expenditure measured in the pre-transplantation in order to compare with post-transplant data. |
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| Post Transplant | All 20 patients will have the energy expenditure measured in the post transplantation in order to compare with the pre-transplant data. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Indirect Calorimetry | Other | In the pre-transplant, before the conditioning regime, and also on the 10th and 17th post-transplant, the resting energy expenditure was measured by indirect calorimetry. |
| Measure | Description | Time Frame |
|---|---|---|
| Energy expenditure | The energy expenditure will be analyzed by the volume of oxygen (VO2) consumed, the volume of carbon dioxide (VCO2) produced and the respiratory quotient (VO2 / VCO2). The values analyzed will be the results of the measures of energy expenditure (BMR) before and after the transplant, in calories (Kcal), to verify changes caused by chemotherapy and / or radiation therapy. | Up to 3 weeks after protocol termination |
| Measure | Description | Time Frame |
|---|---|---|
| Nutritional status of patients | We'll use ASG for this parameter. Patients will have nutritional status classified as malnourished, nourished or overweight, in the periods before and after transplantation to verify changes caused by chemotherapy and / or radiation therapy. | Up to 3 weeks after protocol termination |
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Inclusion Criteria:
Exclusion Criteria:
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All patients of both sexes, older than 15 years old, hospitalized in the Bone Marrow Transplant sector of the Hospital das ClÃnicas of the Federal University of Minas Gerais and submitted to transplantation will be evaluated.
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| Name | Affiliation | Role |
|---|---|---|
| Simone V Generoso | Federal University of Minas Gerais | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Escola de Enfermagem - UFMG | Belo Horizonte | Minas Gerais | 30130-100 | Brazil |
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| ID | Term |
|---|---|
| D002153 | Calorimetry, Indirect |
| ID | Term |
|---|---|
| D002151 | Calorimetry |
| D002623 | Chemistry Techniques, Analytical |
| D008919 | Investigative Techniques |
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| Caloric and protein adequacy |
The caloric and protein adequacy will be analyzed by the amount of calorie (kcal / kg / day) and protein (g / kg / day) intake, compared to calorie and protein required before and after transplantation, to verify changes caused by chemotherapy and / or radiation therapy.The caloric and protein adequacy will be presented with g/kg/day (protein) or kcal/kg/day (calories) |
| Up to 3 weeks after protocol termination |
| Clinical outcomes | Patients will have the following outcomes:
| Up to 3 weeks after protocol termination |