- Interest in the use of HCQ is controversial.

Evaluation of the efficacy and safety of Treatments for Patients Hospitalized for COVID-19 Infection without signs of acute respiratory failure, in Tunisia Multicentric Randomized Comparative Study

Arm 1:

• Hydroxychloroquine (HCQ): 600 mg on the 1st day as a starting dose then 200 mg * 2 /D for 9 days
• Azithromycin: 500 mg (1st day) then 250 mg / D for 4 days
• Usual standard treatment

Arm 2:

• HCQ: 600 mg on the 1st day as a starting dose then 200 mg * 2 / D for 9 days
• Azithromycin: 500 mg (1st day) then 250 mg / D for 4 days
• Zinc: 220 mg per day for 10 days
• Usual standard treatment

Arm 3:

• Azithromycin: 500 mg (1st day) then 250 mg / D for 4 days
• Doxycycline: 200 mg per day for 10 days.
• Usual standard treatment

Inclusion Criteria:

• Confirmed patient COVID19 positive with clinical signs of acute lower respiratory infection with signs of pneumonia or bronchitis: fever and / or cough and / or difficulty breathing in the absence of acute respiratory failure (PaO2> 60 mmHg) with Plus or less :

  • Chills

  • Asthenia, fatigability

  • Headache

  • Arthromas myalgia

  • Dry throat

  • Rhinorrhea

  • An anosmia

  • chest pain

  • Diarrhea

  • Nausea and vomiting

    • Absence of rhythm disturbance (Qt interval <500ms)
    • Patients hospitalized in the medical service
    • 18 years old \