Anosmia and / or Ageusia and Early Corticosteroid Use

Anosmia and / or Ageusia in COVID-19: Timeline, Treatment With Early Corticosteroid and Recovery

Time to recover of Anosmia and / or ageusia and early corticosteroid use

In a study of dexamethasone kinetics in two groups of 15 patients with community-acquired pneumonia, one group was treated with dexamethasone 6 mg/day by mouth and the other with 4 mg/day intravenously. The apparent volume of distribution was 1 L/kg in both groups, but the half-life after oral administration was approximately 7 hours, and after intravenous administration 9 hours. The bioavailability of oral dexamethasone was 81% (95% CI = 54-121%). However, the biological half-life of dexamethasone is much longer, of the order of 36-54 h compared with 18-36 h for prednisolone.

Time to recover of Anosmia and / or ageusia and early corticosteroid use

Inclusion Criteria:

• Any case with COVID-19
• Age more than or equal to 18 years
• Mild to moderate severity

Exclusion Criteria:

• Diabetes
• Any contra-indication for the interventional drug
• Mentally disabled cases