Intracanalicular Dexamethasone Insert for the Treatment of Inflammation and Discomfort in Dry Eye Disease (DEcIDED)

Intracanalicular Dexamethasone Insert for the Treatment of Inflammation and Discomfort in Dry Eye Disease

This prospective, single-center, randomized, double-masked, parallel comparison, sponsored study seeks to investigate the efficacy of Intracanalicular dexamethasone Insert (IDI) on ameliorating the signs and symptoms of dry eye disease.

Inclusion Criteria:

• Diagnosis of Dry Eye Disease
• Objective Signs (Schirmer's II test <10 mm at 5 min; Tear Break-Up time (TBUT) of <10 seconds in 1 eye; corneal fluorescein staining of .=4 in at least 1 eye; conjunctival lissamine green staining of the nasal and temporal conjunctive >=4 in at least 1 eye)
• Ocular inflammation presence confirmed by In-Vivo Confocal Microscopy

Exclusion Criteria:

• History of Diabetes
• History of ocular surgery, corneal infection, or corneal injury within the last 3 months
• Active ocular allergies
• Active ocular infection
• Allergic to benzalkonium chloride