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| Name | Class |
|---|---|
| International Severe Acute Respiratory and Emerging Infection Consortium | OTHER |
| BREATHE Health Data Research Hub | UNKNOWN |
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This study will investigate how the case fatality in hospitalised patients with COVID-19 has changed throughout the pandemic. It will also explore possible mechanisms that could be driving these changes. This analysis will enhance our understanding of the virus, which will be important for researchers and clinicians to respond appropriately.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hospitalisations | All hospitalised COVID patients |
| |
| Critical care | All hospitalised COVID patients in critical care |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Patient Characteristics | Other | Characteristics of the patients |
|
| Measure | Description | Time Frame |
|---|---|---|
| Case fatality | The proportion of new admissions with COVID-19 who died over time | 23 weeks |
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Inclusion Criteria:
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All patients with proven or high likelihood of COVID-19 admitted to the 260 UK hospitals enrolled in the ISARIC-4C study
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| Name | Affiliation | Role |
|---|---|---|
| Annemarie B Docherty | Usher Institute, University of Edinburgh | Principal Investigator |
| Ewen M Harrison | Usher Institute, University of Edinburgh | Principal Investigator |
| Rachel H Mulholland | Usher Institute, University of Edinburgh | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Edinburgh | Edinburgh | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32444460 | Background | Docherty AB, Harrison EM, Green CA, Hardwick HE, Pius R, Norman L, Holden KA, Read JM, Dondelinger F, Carson G, Merson L, Lee J, Plotkin D, Sigfrid L, Halpin S, Jackson C, Gamble C, Horby PW, Nguyen-Van-Tam JS, Ho A, Russell CD, Dunning J, Openshaw PJ, Baillie JK, Semple MG; ISARIC4C investigators. Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. BMJ. 2020 May 22;369:m1985. doi: 10.1136/bmj.m1985. |
| Label | URL |
|---|---|
| ISARIC 4C website | View source |
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Access to all data and samples collected by ISARIC4C are controlled by an Independent Data and Materials Access Committee (IDAMAC), composed of representatives of research funders, academia, clinical medicine, public health and industry. Their job is to ensure that all data and samples are used to generate the greatest possible benefit to humanity, in the shortest possible time.
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| ID | Term |
|---|---|
| D000093485 | COVID-19 Drug Treatment |
| D014218 | Triage |
| D055872 | Surge Capacity |
| ID | Term |
|---|---|
| D004358 | Drug Therapy |
| D013812 | Therapeutics |
| D004632 | Emergency Medical Services |
| D006296 | Health Services |
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| COVID-19 treatments | Other | Specific treatments used on COVID-19 patients |
|
| Differences in triage | Other | Triage criteria for treating COVID-19 patients |
|
| Surge capacity | Other | Capacity of hospitals |
|
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D005159 |
| Health Care Facilities Workforce and Services |
| D006301 | Health Services Needs and Demand |
| D003695 | Delivery of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |