Prospective, multicenter, single arm, post-market study to evaluate real world clinical outcomes in ESRD patients receiving in-home dialysis on the Tablo Hemodialysis System.

Inclusion Criteria:

• Participant (patient and/or care partner) is at least 15 years of age and has provided informed consent and has signed a Health Insurance Portability and Accountability Act of 1996 (HIPAA) compliant authorization statement.
• Participant weighs ≥ 34kg.
• Participant has end stage renal disease (ESRD) adequately treated by maintenance dialysis.
• Participant plans to start or has started home treatment (≤ 6 months) with the Tablo Hemodialysis System.
• Participant is willing and able to comply with the Protocol requirements and perform all site required treatments and clinical evaluations.

Exclusion Criteria:

• Participant and/or care partner is unable to read English or Spanish.
• Participant has a home environment that is deemed inappropriate for home dialysis.
• Participant and/or care partner is unable to successfully complete the Tablo training program
• Participant is pregnant or plans to become pregnant.

Patients with end stage renal disease (ESRD) who are on, or planning to be on, maintenance hemodialysis.