EGDS management strategy was implemented in ICU patients with severe brain injury, the depth of sedation and GCS score were monitored, and the protective effects of EGDS strategy and standard sedation strategy on the brain of patients with severe brain injury were discussed.

Inclusion Criteria:

• Clinical diagnosis of severe craniocerebral injury
• The GCS score is 6 to 12 points
• Within 12 hours of intubation
• The mechanical ventilation time is greater than 24 hours
• Obtain written consent

Exclusion Criteria:

• Pregnant women
• Acute liver failure
• Dementia or mental illness