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Cardiac dysfunction has been reported to be common in patients infected with COVID-19. The aim of this study is to evaluate the clinical importance of cardiac dysfunction in critically ill patients infected with COVID-19.
Cardiac dysfunction has been reported to be common in patients infected with COVID-19. The aim of this study is to evaluate the clinical importance of cardiac dysfunction in critically ill patients with COVID-19. Patients admitted to the intensive care unit, with COVID-19 are examined with echocardiography for assessment of left and right ventricular dysfunction within 72 hours from admission and repeated after four to seven days.
Cardiac dysfunction was defined as having either left ventricular (LV) dysfunction, defined as having an ejection fraction <50% and/or regional hypokinesia, or right ventricular (RV) dysfunction, defined as having a tricuspid annular plane excursion (TAPSE) <17mm or a moderate/severe RV dysfunction assessed visually.
The cardiac biomarkers troponin and NTproBNP and clinical data are recorded at time of each echo. Mortality status is recorded at 30 days.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Echocardiography | Diagnostic Test | Echocardiography for assessment of cardiac function |
| Measure | Description | Time Frame |
|---|---|---|
| Mortality | All cause death in patients with vs without cardiac dysfunction | 30 days |
| Measure | Description | Time Frame |
|---|---|---|
| Left ventricular dysfunction | Prevalence of left ventricular dysfunction | Within 72 hours from admission |
| Right ventricular dysfunction | Prevalence of right ventricular dysfunction |
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Inclusion Criteria: Patients admitted to the intensive care unit infected with COVID-19
Exclusion Criteria:
-
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All patients admitted to participating unit, being infected with COVID-19 are eligible for inclusion
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| Name | Affiliation | Role |
|---|---|---|
| Jonatan Oras, MD, PhD | Sahlgrenska University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Södersjukhuset | Stockholm | Region Stockholm | Sweden | |||
| Sahlgrenska University Hospital/Mölndal |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| D018487 | Ventricular Dysfunction, Left |
| D018497 | Ventricular Dysfunction, Right |
| D006976 | Hypertension, Pulmonary |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| ID | Term |
|---|---|
| D004452 | Echocardiography |
| ID | Term |
|---|---|
| D057791 | Cardiac Imaging Techniques |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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Blood samples
| Within 72 hours from admission |
| Risk-factors | Clinical variables associated with risk of having cardiac dysfunction | Within 72 hours from admission |
| Cardiac biomarkers | Levels of cardiac biomarkers in patients with vs without cardiac dysfunction | Within 72 hours from admission |
| Left ventricular dysfunction | Prevalence of left ventricular dysfunction | During ICU-stay |
| Right ventricular dysfunction | Prevalence of right ventricular dysfunction | During ICU-stay |
| Risk-factors | Clinical variables associated with risk of having cardiac dysfunction | During ICU-stay |
| Cardiac biomarkers | Levels of cardiac biomarkers in patients with vs without cardiac dysfunction | During ICU-stay |
| Gothenburg |
| Västra Götaland County |
| 40530 |
| Sweden |
| Sahlgrenska University Hospital/Östra | Gothenburg | Västra Götaland County | 40530 | Sweden |
| Sahlgrenska University Hospital | Gothenburg | Västra Götaland County | 41345 | Sweden |
| North Älvsborg County Hospital | Trollhättan | Västra Götalandsregionen | Sweden |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D018754 | Ventricular Dysfunction |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D006973 | Hypertension |
| D014652 | Vascular Diseases |
| D014463 | Ultrasonography |
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |