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COVID-19 is a worldwide pandemic. Around 5% of infected patients are admitted in ICU, mainly for respiratory failure. Outcome of these patients is linked to other organ failures. Optimal therapies are not defined so far. The sponsor want to assess the role of MR-ProADM as prognostic biomarker, and the impact of treatments (including supportive treatments) on MOF occurrence and outcome.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MR-Pro-ADM | Other | Dosage of MR-pro-ADM |
| Measure | Description | Time Frame |
|---|---|---|
| Association or correlation between MR-ProADM at day 1 and day 3 and the onset of visceral failures extra respiratory in reanimation. | Association or correlation between MR-ProADM at day 1 and day 3 and the onset of visceral failures extra respiratory in reanimation. | comparison to day 1 and day 3 |
| mortality at day 28 and day 90. | mortality at day 28 and day 90. | admission until day 90 |
| Measure | Description | Time Frame |
|---|---|---|
| Association between MR-ProADM and mortality at day 28. | Association between MR-ProADM and mortality at day 28. | admission until day 28 |
| Association or correlation between patient factor or treatment, and the onset or aggravation of visceral failures (day 3 and day 10), evolution until day 28. |
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Inclusion Criteria:
Exclusion Criteria:
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Any adult patient admitted in the ICU with COVID-19 pneumonia
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital of Arras | Arras | 62000 | France | |||
| Hospital of Boulogne/mer |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| ID | Term |
|---|---|
| C574167 | mid-regional pro-adrenomedullin, human |
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Association or correlation between patient factor or treatment, and the onset or aggravation of visceral failures (day 3 and day 10), evolution until day 28. |
| admission until day 28 |
| Boulogne-sur-Mer |
| 62200 |
| France |
| Hospital of DOUAI | Douai | 59507 | France |
| Hospital of Dunkerque | Dunkirk | 59240 | France |
| Hospital Dr Schaffner | Lens | 62307 | France |
| Hospital of Roubaix | Roubaix | 59100 | France |
| Hospital of Tourcoing | Tourcoing | 59200 | France |
| Hospitalier of Valenciennes | Valenciennes | 59300 | France |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |