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To evaluate the acute effects of respiratory muscle exercises vs. a control intervention on blood glucose kinetics in healthy adults after an oral glucose tolerance test.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Respiratory Muscle Exercises | Experimental | Two respiratory muscle exercises |
|
| Control | No Intervention | The control intervention consists of quiet sitting for 15 min |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 5min respiratory muscle exercises | Other | 5 min of hyperpnea at a target intensity of 60-80% MVV 15-30min after ingestion of 75g of glucose |
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| Measure | Description | Time Frame |
|---|---|---|
| Peak blood glucose concentration | Peak blood glucose concentration will be determined in the three conditions (5min or 15min respiratory muscle exercises or control). | throughout the study, an expected average of 2 weeks per participant |
| area under the glucose-time curve | Area under the glucose-time curve will be determined in the three conditions (5min or 15min respiratory muscle exercises or control). | throughout the study, an expected average of 2 weeks per participant |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Christin M. Spengler, Prof. | Exercise Physiology Lab, Institute of Human Movement Sciences and Sport, ETH Zurich | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Exercise Physiology Lab, Institute of Human Movement Sciences and Sport, ETH Zurich | Zurich | Canton of Zurich | 8057 | Switzerland |
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This study consists of four visits to the laboratory, each separated by at least 24 hours and each lasting approximately 2.5h. Total duration for each participant is approximately 2 weeks. The study is conducted in 40 healthy adults (≥ 18 years). The study is a randomized, controlled cross-over trial. We chose a cross-over design in order to test the effects of different respiratory exercises compared to a control intervention in order to minimize variability since each subject serves as his/her own control. Due to the nature of the intervention (respiratory muscle exercises), it is not possible to blind participants to the interventions.
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| 15min respiratory muscle exercises | Other | 5 min of hyperpnea at a target intensity of 60-70% MVV 15-30min after ingestion of 75g of glucose |
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