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| ID | Type | Description | Link |
|---|---|---|---|
| 2019-A03194-53 | Other Identifier | IDRCB |
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L-tyrosine is a chemical precursor of dopamine. Under specific conditions, tyrosine administration can increase brain dopamine levels and therefore several studies have explored whether tyrosine supplementation can have a beneficial effect on cognitive and behavioural performance that is dependent on dopaminergic function. However, the effects of tyrosine supplementation are mixed: some studies show positive effects while others do not. Stress leads to an increase in dopaminergic activity and turnover in the brain, resulting in a decrease in brain dopamine levels. We propose to study the contribution of tyrosine to decision making and more particularly to the processes of response selection (mediated by the prefrontal cortex and under the influence of the dopaminergic system) in stressful situations.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Tyrosine - Test | Experimental | 4 similar visits (day 0, day 3, day 6, day 9): Administration of L-tyrosine No stress exposure |
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| Tyrosine - Stress | Experimental | 4 similar visits (day 0, day 3, day 6, day 9): Administration of L-tyrosine Stress exposure |
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| Placebo - Test | Experimental | 4 similar visits (day 0, day 3, day 6, day 9): Administration of Placebo No stress exposure |
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| Placebo - Stress | Experimental | 4 similar visits (day 0, day 3, day 6, day 9): Administration of Placebo Stress exposure |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood collection | Biological | A blood sample will be collected before and after treatment administration |
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| Measure | Description | Time Frame |
|---|---|---|
| Reaction Time | Reaction Time at the cognitive tasks | At day 9 (9 days after enrollment) |
| Number of incorrect responses | Number of incorrect responses at the cognitive tasks | At day 9 |
| Measure | Description | Time Frame |
|---|---|---|
| Error negativity | Error negativity on motor evoked potentials (measured by EMG) | At day 9 |
| Correlation coefficient between anxiety level and tyrosinemia | Correlation coefficient between anxiety level (measured by anxiety scale) and tyrosinemia (measured in blood sample) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institut de Recherche Biomédicale des Armées | Brétigny-sur-Orge | 91223 | France |
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The study is composed of 4 arms:
Every participants will participate in the 4 arms in a random order.
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The pharmacist, carrying out the packaging and labelling of the treatment units, will ensure the blinding. Neither the participant nor the investigator will know what treatment is being administered.
| L-Tyrosine 500 Mg | Drug | The participants will be administered 4 capsules of L-Tyrosine 500 mg per oral route |
|
| Placebo | Drug | The participants will be administered 4 capsules of Lactose 500 mg (placebo) per oral route |
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| Cognitive tasks | Behavioral | The participants will perform cognitive decision-making tasks: Simon task and masking task after treatment administration |
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| Stress exposure | Other | Unpleasant but not painful skin stimulations will be administered to the participants at variable intervals on the left leg during the cognitive tasks |
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| Anxiety scale | Behavioral | Spielberger's State Trait Anxiety Inventory (STAI) will be filled by the participants before and after cognitive tasks |
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| Electromyography (EMG) | Device | Electromyography measurements will be performed during cognitive tasks. |
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| Electroencephalography (EEG) | Device | Electroencephalography measurements will be performed during cognitive tasks. |
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| At day 9 |
| Correlation coefficient between anxiety level and plasma tyrosine | Correlation coefficient between anxiety level (measured by anxiety scale) and plasma tyrosine (measured in blood sample) | At day 9 |
| Correlation coefficient between cortisolaemia and melatoninaemia | Correlation coefficient between cortisolaemia and melatoninaemia (measured in blood sample) | At day 9 |
| ID | Term |
|---|---|
| D013315 | Stress, Psychological |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| D014443 | Tyrosine |
| D004576 | Electromyography |
| D004569 | Electroencephalography |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
| D024322 | Amino Acids, Aromatic |
| D000598 | Amino Acids, Cyclic |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
| D004568 | Electrodiagnosis |
| D009213 | Myography |
| D003943 | Diagnostic Techniques, Neurological |
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