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| Name | Class |
|---|---|
| University of California, Los Angeles | OTHER |
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Erythroferrone (ERFE) is a recently identified iron-regulatory hormone that couples iron homeostasis to erythropoiesis but at this time there are no human data on this hormone in pregnant women and their neonates. The investigators hypothesize that ERFE is a sensitive biomarker of iron deficiency and anemia in pregnancy and neonates, and that it mediates the feedback mechanism to correct iron deficiency and anemia. To address this research gap, the investigators will measure ERFE in maternal serum, umbilical cord serum and placental tissue using an existing biospecimen archive.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pregnant Adolescents | |||
| Pregnant Women Carrying Multiple Fetuses |
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| Measure | Description | Time Frame |
|---|---|---|
| Maternal Erythroferrone During Pregnancy | Measures will be obtained from maternal blood collected throughout the 40 weeks of pregnancy | |
| Maternal Erythroferrone at Delivery | Measures will be obtained from maternal blood collected at delivery | |
| Neonatal Erythroferrone at Birth | Measures will be obtained from umbilical cord blood collected at delivery | |
| Placental Erythroferrone mRNA and Ferroportin protein Expression | Measures will be obtained from placental samples collected at delivery |
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Inclusion Criteria:
Exclusion Criteria:
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Pregnant women carrying multiple fetuses (twins, triplets and quadruplets) or pregnant adolescents carrying a single fetus
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| Name | Affiliation | Role |
|---|---|---|
| Kimberly O'Brien, PhD | Cornell University | Principal Investigator |
| Elizabeta Nemeth, PhD | University of California, Los Angeles | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rochester Adolescent Maternity Program | Rochester | New York | 14609 | United States | ||
| Strong Memorial Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33982118 | Derived | Delaney KM, Guillet R, Pressman EK, Ganz T, Nemeth E, O'Brien KO. Serum Erythroferrone During Pregnancy Is Related to Erythropoietin but Does Not Predict the Risk of Anemia. J Nutr. 2021 Jul 1;151(7):1824-1833. doi: 10.1093/jn/nxab093. |
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| ID | Term |
|---|---|
| D000751 | Anemia, Neonatal |
| ID | Term |
|---|---|
| D000740 | Anemia |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D007232 | Infant, Newborn, Diseases |
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During pregnancy 15 mL maternal blood sample collected. At delivery 15 mL maternal blood sample, 20 mL umbilical cord blood sample and the placenta are collected.
| Rochester |
| New York |
| 14620 |
| United States |
| D009358 |
| Congenital, Hereditary, and Neonatal Diseases and Abnormalities |