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| ID | Type | Description | Link |
|---|---|---|---|
| 2020-A00016-33 | Other Identifier | ANSM |
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Aging is associated with multiple deteriorations of the neuromuscular system. Given the increase in life expectancy, the investigators can now distinguish old adults (>60 years old) who conserve their neuromuscular capacities with regular physical activity and very old adults (>80 years old) who suffer from an inexorable decline, even if the number of octogenarians and their quality of life are progressively increasing. However, the most part of the literature on fatigue and neuromuscular capacity with aging focused on isometric tasks. The results showed a significant decrease in maximal force production capacity and a greater resistance to fatigue for old people compared to the young population. When fatigue is induced trough dynamic contractions, greater fatigability was observed in old adults compared to young adults. Investigations performed on the population aged over 80 years old are rare, showing greater fatigability in octogenarians than old men (aged 60-80 years old) during isometric tasks. The knowledge about the effects of dynamic contractions in this population are limited, and performed uniquely in single leg isokinetic mode. Evaluations that require the use of both legs and higher muscle mass involved in the task (cycloergometer) are needed. Understanding neuromuscular fatigue and fatigability across different exercise modalities is necessary to set adapted physical activity programs aimed to maintain autonomy in older individuals.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Young people | Experimental | Men or Women under 35 years old |
|
| Old people | Experimental | Men or Women between 60 and 80 years old |
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| Very old people | Experimental | Men or Women over 80 years old |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mini Mental State Examination | Behavioral | test for evaluating a person's cognitive functions and memory capacity |
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| Measure | Description | Time Frame |
|---|---|---|
| Percentage of Maximum Voluntary Contraction (%) - all participants | The measurement of the maximum voluntary contraction is carried out at rest with the instruction to contract the extensor muscles of the knee as hard as possible by pushing against a fixed pedal. This force is measured by an isokinetic ergometer. | Immediately after pedalling on an ergocycle |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of Maximum Voluntary Contraction (%) - 18-35 years old participants | The measurement of the maximum voluntary contraction is carried out at rest with the instruction to contract the extensor muscles of the knee as hard as possible by pushing against a fixed pedal. This force is measured by an isokinetic ergometer. | Before and immediately after pedalling on an ergocycle |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of voluntary activation (%) | To compare voluntary Activation of the extensor muscles of the knee by peripheral nerve stimulation between 18-35 years old, 60-80 years old and more than 80 years old participants. | Before and immediately after concentric isokinetic contractions |
| Percentage of voluntary activation (%) |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Léonard FEASSON, MD PhD | Centre Hospitalier Universitaire de Saint Etienne | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Saint-Etienne | Saint-Etienne | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39285590 | Derived | Luneau E, Rozand V, Rimaud D, Foschia C, Millet GY. Walking Economy and Preferred Speed in Old and Very Old Men. Med Sci Sports Exerc. 2025 Feb 1;57(2):400-412. doi: 10.1249/MSS.0000000000003565. Epub 2024 Sep 17. | |
| 37580874 | Derived | Varesco G, Luneau E, Millet GY, Feasson L, Lapole T, Rozand V. Age-Related Differences between Old and Very Old Men in Performance and Fatigability Are Evident after Cycling but Not Isometric or Concentric Single-Limb Tasks. Med Sci Sports Exerc. 2023 Sep 1;55(9):1641-1650. doi: 10.1249/MSS.0000000000003181. Epub 2023 Apr 4. |
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| 6 Minutes Walk Test | Diagnostic Test | a standardized test of an individual's functional ability that involves walking the greatest distance a person can walk in six minutes. This walking may be limited by shortness of breath or fatigability. |
|
| Timed up and go | Diagnostic Test | A simple test used to assess a person's mobility and requires both static and dynamic balance. It uses the time it takes for a person to get up from a chair, walk three metres, turn around, walk to the chair and sit down. |
|
| Isokinetic Body weight-based quadriceps intermittent fatigue test (BW-QIF Test) | Diagnostic Test | The BW-QIF test is an interval incremental contraction test including blocks of discontinuous 100-s effort. Neuromuscular evaluation of the knee extensors between blocks (duration 25 s) includes one maximal voluntary contraction, one contraction at the 60% of the actual maximal force and at the 80% of the actual maximal force. During each contraction, transcranial magnetic stimulation over the motor cortex will be delivered to assess corticospinal voluntary activation (central fatigue). Single-twitch electrical stimulations will be delivered on the femoral nerve during the maximal voluntary contraction and at rest to evaluate peripheral fatigue. The isokinetic BW-QIF test blocks consist in 100 contractions at 120° deg.s-1 and 60° of range of motion (0.5-s contraction /0.5-s rest). |
|
| Cycloergometer body weight-based quadriceps intermittent fatigue test (BW-QIF Test) | Diagnostic Test | The BW-QIF test is an interval incremental contraction test including blocks of discontinuous 100-s effort. Neuromuscular evaluation of the knee extensors between blocks (duration 25 s) includes one maximal voluntary contraction, one contraction at the 60% of the actual maximal force and at the 80% of the actual maximal force. During each contraction, transcranial magnetic stimulation over the motor cortex will be delivered to assess corticospinal voluntary activation (central fatigue). Single-twitch electrical stimulations will be delivered on the femoral nerve during the maximal voluntary contraction and at rest to evaluate peripheral fatigue. The BW-QIF test blocks on the cycloergometer consist in 100 s of cycling at 60 Revolution Per Minute (RPM). |
|
| Isometric BW-QIF Test (Body weight-based quadriceps intermittent fatigue test) | Diagnostic Test | The BW-QIF test is an interval incremental contraction test including blocks of discontinuous 100-s effort. Neuromuscular evaluation of the knee extensors between blocks (duration 25 s) includes one maximal voluntary contraction, one contraction at the 60% of the actual maximal force and at the 80% of the actual maximal force. During each contraction, transcranial magnetic stimulation over the motor cortex will be delivered to assess corticospinal voluntary activation (central fatigue). Single-twitch electrical stimulations will be delivered on the femoral nerve during the maximal voluntary contraction and at rest to evaluate peripheral fatigue. The isometric BW-QIF test blocks consist in 10 contractions (5-s contraction / 5-s rest). |
|
| Percentage of Maximum Voluntary Contraction (%) - 60-80 years old participants | The measurement of the maximum voluntary contraction is carried out at rest with the instruction to contract the extensor muscles of the knee as hard as possible by pushing against a fixed pedal. This force is measured by an isokinetic ergometer. | Before and immediately after pedalling on an ergocycle |
| Percentage of Maximum Voluntary Contraction (%) - more than 80 years old participants | The measurement of the maximum voluntary contraction is carried out at rest with the instruction to contract the extensor muscles of the knee as hard as possible by pushing against a fixed pedal. This force is measured by an isokinetic ergometer. | Before and immediately after pedalling on an ergocycle |
| Percentage of Maximum Voluntary Contraction (%) - more than 80 years old participants | The measurement of the maximum voluntary contraction is carried out at rest with the instruction to contract the extensor muscles of the knee as hard as possible by pushing against a fixed pedal. This force is measured by an isokinetic ergometer. | Before and immediately after isometric contractions |
| Percentage of Maximum Voluntary Contraction (%) - 60-80 years old participants | The measurement of the maximum voluntary contraction is carried out at rest with the instruction to contract the extensor muscles of the knee as hard as possible by pushing against a fixed pedal. This force is measured by an isokinetic ergometer. | Before and immediately after isometric contractions |
| Percentage of Maximum Voluntary Contraction (%) - 18-35 years old participants | The measurement of the maximum voluntary contraction is carried out at rest with the instruction to contract the extensor muscles of the knee as hard as possible by pushing against a fixed pedal. This force is measured by an isokinetic ergometer. | Before and immediately after isometric contractions |
| Percentage of Maximum Voluntary Contraction (%) - 18-35 years old participants | The measurement of the maximum voluntary contraction is carried out at rest with the instruction to contract the extensor muscles of the knee as hard as possible by pushing against a fixed pedal. This force is measured by an isokinetic ergometer. | Before and immediately after concentric isokinetic contractions |
| Percentage of Maximum Voluntary Contraction (%) - 60-80 years old participants | The measurement of the maximum voluntary contraction is carried out at rest with the instruction to contract the extensor muscles of the knee as hard as possible by pushing against a fixed pedal. This force is measured by an isokinetic ergometer. | Before and immediately after concentric isokinetic contractions |
| Percentage of Maximum Voluntary Contraction (%) - more than 80 years old participants | The measurement of the maximum voluntary contraction is carried out at rest with the instruction to contract the extensor muscles of the knee as hard as possible by pushing against a fixed pedal. This force is measured by an isokinetic ergometer. | Before and immediately after concentric isokinetic contractions |
To compare voluntary Activation of the extensor muscles of the knee by peripheral nerve stimulation between 18-35 years old, 60-80 years old and more than 80 years old participants. |
| Before and immediately after isometric contractions |
| Percentage of voluntary activation (%) | To compare voluntary Activation of the extensor muscles of the knee by peripheral nerve stimulation between 18-35 years old, 60-80 years old and more than 80 years old participants. | Before and immediately after pedalling on an ergocycle |
| Difference in amplitude of electric shock at rest (% of shock) | To compare the amplitude of the electric shock at rest of the extensor muscles of the knee between 18-35 years old, 60-80 years old and more than 80 years old participants. | Before and immediately after pedalling on an ergocycle |
| Difference in amplitude of electric shock at rest (% of shock) | To compare the amplitude of the electric shock at rest of the extensor muscles of the knee between 18-35 years old, 60-80 years old and more than 80 years old participants. | Before and immediately after isometric contractions |
| Difference in amplitude of electric shock at rest (% of shock) | To compare the amplitude of the electric shock at rest of the extensor muscles of the knee between 18-35 years old, 60-80 years old and more than 80 years old participants. | Before and immediately after concentric isokinetic contractions |
| ID | Term |
|---|---|
| D000073216 | Mental Status and Dementia Tests |
| D000070857 | Walk Test |
| ID | Term |
|---|---|
| D009483 | Neuropsychological Tests |
| D011581 | Psychological Tests |
| D004191 | Behavioral Disciplines and Activities |
| D005080 | Exercise Test |
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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