Shivering and Glucose Homeostasis

The Effect of Prolonged Shivering Thermogenesis on Glucose Homeostasis in Overweight/Obese Humans

The purpose of this study is to investigate the effect of prolonged shivering thermogenesis on glucose homeostasis in overweight/obese humans.

Inclusion Criteria:

• Signed informed consent
• Caucasian
• Healthy (as determined by dependent physician based on medical questionnaire)
• Man, or postmenopausal (defined as at least 1year post cessation of menses) woman
• Aged 40 - 75 years at the start of the study
• BMI 27 and 35 kg/m2
• Stable dietary habits (no weight loss or gain >3kg in the past 3 months)

Exclusion Criteria:

• - Not meeting all inclusion criteria
• Medication use known to hamper subject's safety during study procedures
• Co-morbidities to which the intervention or program that may pose as a complicating factor
• Subjects diagnosed with cardiovascular diseases or cancer
• Fasting plasma glucose ≥ 7.0 mmol/l
• Haemoglobin < 7.8 mmol/l for women, or < 8.4 mmol/l for men
• Previously diagnosed with type 2 diabetes
• Abuse alcohol/drug abuse
• Subjects who do not want to be informed about unexpected medical findings during the screening/study or do not wish that their physician is informed.
• Engagement in structured exercise > 2h per week
• Participation in another biomedical study within 1 month before the first study
• Smoking
• Cold-acclimated, such as takes daily extended cold baths, works in a refrigerated environment, or regular cold-water swimming within 1 month of starting the study