Changes of Trace Elements in Aqueous Humor, Blood and Tea... | NCT04515030

NCT04515030

Protocol Section

Identification Module

Results Section

No data available

No data is available for this block.

Annotation Section

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No data is available for this block.

Document Section

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No data is available for this block.

Derived Section

Miscellaneous Info Module

Status Module

Description Module

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Primary glaucoma		Primary glaucoma patients were diagnosed based on guidelines [1-2]. Patients with a confirmed diagnosis of primary glaucoma were enrolled and classified into the acute angle-closure crisis (AACC), primary angle-closure glaucoma (PACG), and primary open-angle glaucoma (POAG) subgroups. Prum BE, Herndon LW, Moroi SE, et al. Primary Angle Closure Preferred Practice Pattern® Guidelines. Ophthalmology 2016;123:P1-40. doi:10.1016/j.ophtha.2015.10.049 Prum BE, Rosenberg LF, Gedde SJ, et al. Primary Open-Angle Glaucoma Preferred Practice Pattern® Guidelines. Ophthalmology 2016;123:P41-111. doi:10.1016/j.ophtha.2015.10.053
Senile cataract		Senile cataract patients were diagnosed based on guideline [3]. Patients with a confirmed diagnosis of senile cataract were enrolled and considered as controls for aqueous humor-related analysis. [3] Olson RJ, Braga-Mele R, Chen SH, et al. Cataract in the Adult Eye Preferred Practice Pattern®. Ophthalmology 2017;124:P1-119. doi:10.1016/j.ophtha.2016.09.027
Normal control		Normal people without ocular diseases were enrolled as normal control.

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
The concentrations of trace elements in aqueous humor, blood, and tears.	The aqueous humor, blood, and tears samples were collected from patients with primary glaucoma, senile cataract, and normal people. The concentrations of trace elements were measured by inductively coupled plasma mass spectrometry (FI-ICP-MS), metabonomics and genomics.	Specimens were collected before and after surgery for approximately 1 years.

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

- If you meet the following conditions, you can participate in our study and become a subject in the case group:

those who are over 50 years old and can complete all the examinations and examinations.
other secondary and developmental factors have been excluded and diagnosed as primary glaucoma.
before anti-glaucoma surgery, you can take part in blood sampling examination and collect sufficient tears, and sufficient aqueous humor can be collected during the operation.

If you meet the following conditions, you can participate in our study and become a subject in the disease control group:

those who are over 18 years old and can complete all the tests and examinations.
other factors have been excluded and age-related cataract has been clearly diagnosed.
before cataract surgery, you can take part in blood sampling examination and collect sufficient tears, and sufficient aqueous humor can be collected during the operation.

If you meet the following conditions, you can participate in our study and become a normal control group:

those who are over 50 years old and can complete all the tests and examinations.
No previous history of ophthalmopathy (except ametropia, strabismus and age-related cataract).
normal eye examination (intraocular pressure < 21mmHg, chamber angle open, cup / plate ratio normal, visual field normal).
can cooperate with those who take part in blood test and collect enough tears. -

Exclusion criteria:

those who have a history of eye trauma, eye surgery or eye laser.
elevated intraocular pressure and glaucoma optic nerve damage caused by secondary or developmental factors (such as neovascularization, uveitis, trauma, lens-related factors, surgery, drugs, etc.).
suffering from other eye diseases that may affect metabolism (such as uveitis, ocular neovascularization, age-related macular degeneration, etc.) and major systemic diseases (such as heart disease, hypertension, hyperlipidemia, diabetes, hepatitis, digestive tract malabsorption, hypothyroidism, vitamin deficiency, mental illness, severe psoriasis, malignant tumors, etc.).
pregnant, lactating and pregnant women.
those who refuse to sign the informed consent form due to discomfort or other reasons or voluntarily withdraw from the researcher.
those who are unable to cooperate with the relevant inspection and inspection

Name	Affiliation	Role
Yiqing Li	Zhongshan Ophthalmic Center, Sun Yat-sen University, China	Principal Investigator

Facility	Status	City	State	ZIP	Country	Contacts
Zhongshan Ophthalmic Center, Sun Yat-sen University		Guangzhou	Guangdong	510060	China

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
15158634	Background	Weinreb RN, Khaw PT. Primary open-angle glaucoma. Lancet. 2004 May 22;363(9422):1711-20. doi: 10.1016/S0140-6736(04)16257-0.
28049831	Background	Li Y, Andereggen L, Yuki K, Omura K, Yin Y, Gilbert HY, Erdogan B, Asdourian MS, Shrock C, de Lima S, Apfel UP, Zhuo Y, Hershfinkel M, Lippard SJ, Rosenberg PA, Benowitz L. Mobile zinc increases rapidly in the retina after optic nerve injury and regulates ganglion cell survival and optic nerve regeneration. Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E209-E218. doi: 10.1073/pnas.1616811114. Epub 2017 Jan 3.