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Platinum-sensitive is an important basis for the treatment of recurrent epithelial ovarian cancer (EOC) without effective methods to predict.We aimed to develop and validate the EOC deep learning system to predict the platinum-sensitive of EOC patients through analysis of enhanced magnetic resonance imaging (MRI) images before initial treatment.Ninety-three EOC patients received platinum-based chemotherapy (>= 4 cycles) and debulking surgery from Sun Yat-sen Memorial Hospitalin China from January 2011 to January 2020 were enrolled. This deep-learning EOC signature achieved a high predictive power for platinum-sensitive, and the signature based on MRI whole volume is better than that on primary tumor area only.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| platinum-resistant group |
| ||
| platinum-sensitive group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Radiomic Algorithm | Other | Different radiomic and machine learning strategies for radiomic features extraction, sorting features and model constriction |
|
| Measure | Description | Time Frame |
|---|---|---|
| Platinum sensitivity | Platinum sensitivity | 9 years |
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Inclusion Criteria:
Exclusion Criteria:
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Patients received platinum-based chemotherapy (>= 4 cycles) and debulking surgery from Sun Yat-sen Memorial Hospital in China from January 2011 to January 2020
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ruilin Lei, phD | Contact | +8618898325866 | leiruilin1988@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sun Yat-Sen Memorial Hospital of Sun Yat-sen University | Recruiting | Guangzhou | Guangdong | 510120 | China |
The datasets used or analysed during the current study are available from the corresponding author on reasonable request.
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