This is an open-label, Phase 2/3，multicenter and single-arm clinical trial of Camrelizumab plus decitabine for Anti-PD-1 treatment-naive patients with relapsed or refractory Hodgkin Lymphoma. The primary objective of this study is to evaluate the long-term response duration with Camrelizumab plus decitabine in relapsed or refractory Hodgkin Lymphoma.

Inclusion Criteria:

• 1 Subjects must have histological confirmation of relapsed or refractory Hodgkin lymphoma (HL).
• 2 12 to 75 years of age.
• 3 ECOG performance of less than 2.
• 4 Life expectancy of at least 3 months.
• 5 Subjects with lymphoma must have at least one measureable lesion >1 cm as defined by lymphoma response criteria.
• 6 Subjects must have received at least two lines of prior regimens without Anti-PD-1 antibody treatment history, and must be off therapy for at least 4 weeks prior to Day 1. Subjects with autologous hematopoietic stem-cell transplantation are eligible which must be more than 3 months.
• 7 Subjects must have adequate marrow, live, renal and heart functions.

Exclusion Criteria:

• 1 Subjects with any autoimmune disease or history of syndrome that requires corticosteroids or immunosuppressive medications.
• 2 Serious uncontrolled medical disorders or active infections, pulmonary infection especially.
• 3 Active alimentary tract hemorrhage or history of alimentary tract hemorrhage in 1 month .
• 4 Prior organ allograft.
• 5 Women who are pregnant or breastfeeding.
• 6 Women with a positive pregnancy test on enrollment or prior to nvestigational product administration.
• 7 Subjects who are compulsorily detained for treatment of either a psychiatric or physical (eg, infectious disease) illness.