Liver Glycogen Dynamics

Liver Glycogen Dynamics and Substrate Oxidation in Lean Healthy Volunteers

The purpose of this study is to investigate the effect of prolonged overnight fasting in the hepatic glycogen stores

Inclusion Criteria:

• Participants are able to provide signed and dated written informed consent prior to any study specific procedures
• Caucasian (people will be excluded when having a ≥50% racial African/Asian background)
• Participants should have suitable veins for cannulation or repeated venipuncture
• Women are post-menopausal (defined as at least 1 year post cessation of menses)
• Men and women aged ≥ 45 and ≤ 75 years at the start of the study
• Body mass index (BMI) 18.5 - 25 kg/m2
• Stable dietary habits (no weight loss or gain >3kg in the past 3 months)
• Sedentary lifestyle (not more than 3 hours of vigorous sports per week)

Exclusion Criteria:

• Type 2 Diabetes Mellitus
• Active diseases (cardiovascular, diabetes, liver, kidney, cancer or other)
• Any contraindication for MRI scanning
• Alcohol consumption of >2 servings per day
• Regular smoking
• No use of medication interfering with investigated study parameters (as determined by responsible physician)
• Participants who do not want to be informed about unexpected medical findings, or do not wish that their physician