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A randomized, controlled, single-center, exploratory clinical research method was used. In the treatment plan, the experimental group used basic treatment + Huperzine A, and the control group only used basic treatment, with a total of 20 cases. To evaluate the effectiveness and safety of Huperzine A injection in the treatment of brain injury in patients with hypertensive cerebral hemorrhage.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental：Huperzine A for Injection+Basic treatment | Experimental | Huperzine A for Injection: Dissolve each bottle with 2ml sterile water for injection and inject into muscle, the course of treatment is 14 days； Basic treatment：Control blood pressure; prevent continued bleeding; prevent and treat gastrointestinal bleeding; decide whether to perform dehydration treatment according to the condition to reduce cerebral edema; prevent infection, prevent various complications, etc.; routine rehabilitation training. |
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| Control：Basic treatment | No Intervention | Basic treatment：Control blood pressure; prevent continued bleeding; prevent and treat gastrointestinal bleeding; decide whether to perform dehydration treatment according to the condition to reduce cerebral edema; prevent infection, prevent various complications, etc.; routine rehabilitation training. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Huperzine A for Injection | Drug | Give the patient one intramuscular injection (0.2mg) of Huperzine A of injection once a day for 14 days |
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| Measure | Description | Time Frame |
|---|---|---|
| Extension of Glasgow Outcome Scale(GOSE) Scores at 90 days of treatment | At the 90-day follow-up of patients, the extended Glasgow Outcome Scale (GOSE) was used to assess and judge the difference in consciousness after stroke between the two groups. The scores of minimum values is 1, the maximum values is 8, whether higher scores mean a better outcome. | At the 90-day |
| Measure | Description | Time Frame |
|---|---|---|
| Extension of Glasgow Outcome Scale(GOSE) Scores at 30 days of treatment | At the 30-day follow-up of patients, the extended Glasgow Outcome Scale (GOSE) was used to assess and judge the difference in consciousness after stroke between the two groups. The scores of minimum values is 1, the maximum values is 8, whether higher scores mean a better outcome. | At the 30-day |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Fu Xudong, PhD | Contact | 13733167393 | fxd1064@126.com | |
| Zhou Shaolong, PhD | Contact | 13838182963 | 13838182963@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Fifth Affiliated Hospital of Zhengzhou University | Zhengzhou | Henan | 410103 | China |
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| ID | Term |
|---|---|
| D012678 | Sensation Disorders |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| C050426 | huperzine A |
| D007267 | Injections |
| ID | Term |
|---|---|
| D004333 | Drug Administration Routes |
| D004358 | Drug Therapy |
| D013812 | Therapeutics |
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Patients with hypertensive basal ganglia cerebral hemorrhage
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| Scores of Modified Rankin Scale(mRS) at 14 days of treatment | At 14 days of treatment, the two groups of patients were scored with scores of Modified Rankin Scale(mRS). The mRS score of the two groups were compared whether there were statistical differences. The scores of minimum values is 0, the maximum values is 5, whether higher scores mean a worse outcome. | At the 14-day |
| Scores of Modified Rankin Scale(mRS) at 30 days of treatment | At 30 days of treatment, the two groups of patients were scored with scores of Modified Rankin Scale(mRS). The mRS score of the two groups were compared whether there were statistical differences.The scores of minimum values is 0, the maximum values is 5, whether higher scores mean a worse outcome. | At the 30-day |
| Scores of Modified Rankin Scale(mRS) at 90 days of treatment | At 90 days of treatment, the two groups of patients were scored with scores of Modified Rankin Scale(mRS). The mRS score of the two groups were compared whether there were statistical differences.The scores of minimum values is 0, the maximum values is 5, whether higher scores mean a worse outcome. | At the 90-day |
| Scores of National Institute of Health stroke scale(NIHSS) at 14 days of treatment | At 14 days of treatment, the two groups of patients were scored with scores of National Institute of Health stroke scale(NIHSS). The NIHSS score of the two groups were compared whether there were statistical differences. The scores of minimum values is 0, the maximum values is 42, whether higher scores mean a worse outcome. | At the 14-day |
| Scores of National Institute of Health stroke scale(NIHSS) at 30 days of treatment | At 30 days of treatment, the two groups of patients were scored with scores of National Institute of Health stroke scale(NIHSS). The NIHSS score of the two groups were compared whether there were statistical differences. The scores of minimum values is 0, the maximum values is 42, whether higher scores mean a worse outcome. | At the 30-day |
| Scores of National Institute of Health stroke scale(NIHSS) at 90 days of treatment | At 90 days of treatment, the two groups of patients were scored with scores of National Institute of Health stroke scale(NIHSS). The NIHSS score of the two groups were compared whether there were statistical differences. The scores of minimum values is 0, the maximum values is 42, whether higher scores mean a worse outcome. | At the 90-day |
| Scores of the Barthelindex of ADL at 14 days of treatment | At 14 days of treatment, the two groups of patients were scored with scores of Barthelindex of ADL. The Barthelindex of ADL scores of the two groups were compared whether there were statistical differences. The scores of minimum values is 0, the maximum values is 100, whether higher scores mean a better outcome. | At the 14-day |
| Scores of the Barthelindex of ADL at 30 days of treatment | At 30 days of treatment, the two groups of patients were scored with scores of Barthelindex of ADL. The Barthelindex of ADL scores of the two groups were compared whether there were statistical differences. The scores of minimum values is 0, the maximum values is 100, whether higher scores mean a better outcome. | At the 30-day |
| Scores of the Barthelindex of ADL at 90 days of treatment | At 90 days of treatment, the two groups of patients were scored with scores of Barthelindex of ADL. The Barthelindex of ADL scores of the two groups were compared whether there were statistical differences. The scores of minimum values is 0, the maximum values is 100, whether higher scores mean a better outcome. | At the 90-day |
| Complication rate | After 90 days of treatment, compare whether the incidence of complications (including epilepsy, hydrocephalus, infarction, rebleeding, pneumonia, gastrointestinal hemorrhage) between the two groups is statistically different | At the 90-day |