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| Name | Class |
|---|---|
| Ain Shams University | OTHER |
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Aluminium Phosphide is a pesticide used in developing countries to prevent rodents and pests from spoiling the harvested grains. it is presented as tablets which can be administered accidently to humans or for committing suicide. this pesticide is fatal even in small concentration as mortality rate can reach 75- 100% of cases. in this study researchers tried to add some supplements to the routine treatment to improve and decrease the fatality rate.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control group | Placebo Comparator | this group will have the standard and routine therapy of treatment of acute Aluminium Phosphide poisoning immediately after admission according to PCCA guidelines |
|
| N- acetyl cysteine grouo | Active Comparator | N-acetyl cysteine will be given at dose of 300mg/kg/d IV in the first day then 150 mg/kg/d IV in addition to standard of care according to PCCA guidelines |
|
| Acetyl L-carnitine group | Active Comparator | Acetyl L-carnitine will be given at dose of 50 mg/kg IV once to be followed by additional doses of 15 mg/kg IV q4hr infused over 30 min. standard of care according to PCCA guidelines will also be provided |
|
| Medicated paraffin oil group | Active Comparator | Gastric decontamination with sodium bicarbonate (NaHCO3; 44 mEq, orally) and medicated paraffin oil (200 mL) will be administered in addition to standard of care according to PCCA guidelines |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| N-acetyl cysteine | Drug | a drug which can have an off label use as an antidot for aluminium phosphide poisoning in addition to sodium bicarbonate and ondansetron as standard of care |
| Measure | Description | Time Frame |
|---|---|---|
| mortality rate reduction | the primary end point is to lower the mortality rate for patients poisoned with aluminium phosphide pellets | 1 year |
| organ damage reduction | another primary end point is to reduce organ damage and injury for survivors | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mahmoud Sakr, PhD | Contact | +201117922833 | mahmoud.sakr@hotmail.com | |
| Hanan Abdel Wahab, Master's | Contact | +201062261010 | hanan.abdelwahab@yahoo.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Poison Control Center of Ain-Shams University hospitals | Cairo | Abbasya | 11311 | Egypt |
individual paticipant data is decided not to be shared for the privacy of the patients as patients in each group will be coded in numbers instead of their names
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| acetyl L-carnitine | Dietary Supplement | Naturallu occuring amino acid derivative which can be taken as a dietary supplement involves in mitochondrial function and energy production and is suggested to have a role in lowering organ damage resulting from aluminium phosphide poisonong in addition to sodium bicarbonate and ondansetron as standard of care |
|
| medicated paraffin oil | Drug | refined mixture of liquid hydrocarbons which used as laxative and is suggested to reduce absorption of aluminium phosphide if taken within two hours of administration of the toxin in addition to sodium bicarbonate and ondansetron as standard of care |
|
| Sodium Bicarbonate Powder and ondansetron | Drug | standard of care for treatment of aluminuim phosphide is provided for patients poisoned with aluminuim phosphide |
|
| ID | Term |
|---|---|
| D000111 | Acetylcysteine |
| D000108 | Acetylcarnitine |
| D017294 | Ondansetron |
| ID | Term |
|---|---|
| D003545 | Cysteine |
| D000603 | Amino Acids, Sulfur |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
| D002331 | Carnitine |
| D050337 | Trimethyl Ammonium Compounds |
| D000644 | Quaternary Ammonium Compounds |
| D000588 | Amines |
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D002227 | Carbazoles |
| D007211 | Indoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006575 | Heterocyclic Compounds, 3-Ring |
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