Comparison of Extra Vascular Lung Water Index in Covid-19 ARDS and "Typical"ARDS Patients

Comparison of Extra Vascular Lung Water Index in Covid-19 ARDS and "Typical"ARDS Patients

Covid-19 also primarily affects endothelium that line up the alveoli. The resulting hypoxemia may differ from "typical" Acute Respiratory Distress Syndrome (ARDS) due to maldistribution of perfusion related to the ventilation. Thus, pathophysiology of Covid-19 ARDS is different, which requires different interventions than typical ARDS. The investigators will assess whether extravascular lung water index and permeability of the alveolar capillary differs from typical ARDS with transpulmonary thermodilution (TPTD) technique. Extravascular Lung Water Index (EVLWI) and Pulmonary Vascular Permeability Index (PVPI) will be compared.

Inclusion Criteria:

• ARDS defined by Berlin Criteria longer than 24 hours
• Undergoing mechanical ventilation
• Noradrenaline demand >0.1 mcg/kg/min

Exclusion Criteria:

• Not meeting ARDS criteria
• Noninvasive mechanical ventilation
• ARDS resolved shorter than 24 hours
• Shock resolved