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Lack of Funding
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Covid-19 also primarily affects endothelium that line up the alveoli. The resulting hypoxemia may differ from "typical" Acute Respiratory Distress Syndrome (ARDS) due to maldistribution of perfusion related to the ventilation. Thus, pathophysiology of Covid-19 ARDS is different, which requires different interventions than typical ARDS. The investigators will assess whether extravascular lung water index and permeability of the alveolar capillary differs from typical ARDS with transpulmonary thermodilution (TPTD) technique. Extravascular Lung Water Index (EVLWI) and Pulmonary Vascular Permeability Index (PVPI) will be compared.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Typical ARDS | ARDS due to non Covid19 causes |
| |
| C-ARDS | ARDS due to Covid19 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Extravascular Lung Water Index | Device | Measurement of the EVLWI |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Extravascular Lung Water Index | The amount of fluid accumulated in the lung measured by transpulmonary thermodilution (ml/kg) | 1 day |
| Pulmonary vascular permeability index | Integrity of the alveolocapillary barrier measured by transpulmonary thermodilution | 1 day |
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Inclusion Criteria:
Exclusion Criteria:
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All patients with ARDS in the adult ICU that have a TPTD catheter inserted since 2018 will be eligible for recruitment
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| Name | Affiliation | Role |
|---|---|---|
| Yalım Dikmen, Prof | Istanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Istanbul University-Cerrahpaşa | Istanbul | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28625165 | Result | Monnet X, Teboul JL. Transpulmonary thermodilution: advantages and limits. Crit Care. 2017 Jun 19;21(1):147. doi: 10.1186/s13054-017-1739-5. |
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Data available on reasonable request
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| Pulmonary Vascular Permeability Index |
| Device |
Measurement of the PVPI |
|
| ID | Term |
|---|---|
| D012128 | Respiratory Distress Syndrome |
| D011654 | Pulmonary Edema |
| D000086382 | COVID-19 |
| D055371 | Acute Lung Injury |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D012120 | Respiration Disorders |
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D014777 | Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D055370 | Lung Injury |
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