Metabolic Consequences of Cross-sex Hormonal Treatment

Metabolic Consequences of Cross-sex Hormonal Treatment in Transgender Persons

Retrospective study in a single academic regional transgender referral center. Analyse VAT, body composition and metabolic parameters in non-obese transgender subjects one year after starting gender-affirming hormone therapy and in controls

Inclusion Criteria (retrospective analysis of available data as a part of the regular care of subjects with gender dysphoria. All measurements were made at the time of the routine follow-up visits)

• age >= 16 years (Tanner stage IV) and <= 50 years at the initiation of gender-affirming hormone therapy;
• BMI < 28 kg/m2 at the initiation of cross-sex hormonal treatment.

Exclusion Criteria:

• hormonal contraception
• previous gender-affirming hormonal treatment
• previous gender-affirming surgery
• recognized syndrome or chromosomal defect, known metabolic or inflammatory disease, skeletal dysplasia, or chronic corticosteroid treatment.