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This study aims to measure diaphragmatic dysfunction with ultrasonography and nerve stimulation of the phrenicus nerve, in patients undergoing thoracic surgery for lung and esophageal cancer, and correlate measures of diaphramatic function to clinical postoperative endpoints.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients undergoing Thoracic Surgery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lung lobectomy OR esophagus cancer resection | Procedure | Lunge lobectomy (total) Resection of esophagus cancer |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in excursion of the diaphragm | Ultrasonographic measure with M-mode of Diaphragmatic Excursion on right hemidiaphragm | Prior to surgery to 14 days after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Ultrasonographic measure of the difference in Intrathoracic Area | Intrathoracic Area is measured at inspiration and expiration to calculate the difference in Intrathoracic Area during breathing | Prior to surgery to 14 days after surgery |
| Change in Diaphragmatic Thickening Fraction |
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Inclusion Criteria:
Exclusion Criteria:
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Patients scheduled for resection surgeries for either lung or esophagus cancer.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anaesthesiology and Intensive Care East Section, Aarhus University Hospital | Aarhus N | 8200 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38546897 | Derived | Norskov J, Skaarup SH, Bendixen M, Tankisi H, Morkved AL, Juhl-Olsen P. Diaphragmatic dysfunction is associated with postoperative pulmonary complications and phrenic nerve paresis in patients undergoing thoracic surgery. J Anesth. 2024 Jun;38(3):386-397. doi: 10.1007/s00540-024-03325-5. Epub 2024 Mar 28. |
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| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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Ultrasonographic measurement |
| Prior to surgery to 14 days after surgery |
| Change in Intercostal Muscle Thickening Fraction | Ultrasonographic measurement | Prior to surgery to 14 days after surgery |
| Change in forced expired volume within the first second (FEV1) | Spirometry | Prior to surgery to 14 days after surgery |
| Change in forced vital capacity (FEV) | Spirometry | Prior to surgery to 14 days after surgery |
| Change in peak flow | Spirometry | Prior to surgery to 14 days after surgery |
| Change in Electromyographic measure of Maximal Diaphragmatic Response after stimulating the phrenic nerve | Prior to surgery to 14 days after surgery |
| Change in Electromyographic measure of Latency of Diaphragmatic Response after stimulating the phrenic nerve | Prior to surgery to 14 days after surgery |
| Change in 6 Minutes Walk Test | Maximum Walking Distance within 6 minutes | Prior to surgery to 14 days after surgery |
| Change in visual analogue scale score | Scoring system for subjective sensation of pain ranging from 0 to 10. Higher numbers signify higher pain sensations | Prior to surgery to 14 days after surgery |
| Accumulated Opiod Use after Surgery | Morphine equivalents | Prior to surgery to 14 days after surgery |
| Postoperative Pulmonary Complications | Comprising:
| Prior to surgery to 30 days after surgery |
| Admission days at the Intensive Care Unit after Surgery | Prior to surgery to 60 days after surgery |
| Number of Admissions after Discharge from the Surgical Department | Prior to surgery to 60 days after surgery |
| Accumulated Admission Days at any Hospital | Prior to surgery to 60 days after surgery |