Reducing Sedentary Time in Patients With Mild Cognitive Impairment: The Take a STAND for Health Study

Reducing Sedentary Time in Patients With Mild Cognitive Impairment: The Take a STAND for Health Study TS4H-MCI

This research program aims to comprehensively investigate the clinical, physiological, metabolic, and molecular effects of reducing sedentary behavior in patients with mild cognitive impairment. A 4-month parallel-group randomized controlled trial will be conducted aiming to investigate the feasibility and efficacy of a newly developed personalized intervention focused on replacing sedentary time with light-(or very light-) intensity physical activity in patients with mild cognitive impairment. Additionally, a sub-sample of patients will complete a randomised cross-over study aiming to unravel potential mechanisms underlying the metabolic, physiological and molecular effects of breaking up sedentary time with light-intensity physical activity versus carrying out the minimum amount of daily exercise at once and then remaining sedentary versus simply remaining sedentary throughout all sessions, in a well-controlled laboratorial condition.

Inclusion Criteria:

• Middle-aged and older adults with mild cognitive impairment confirmed by a team of neurologists from the CEREDIC HC-FMUSP

Exclusion Criteria:

• Patients who spend less than 8 hours per day in sedentary time
• Patients who are physically active (more than 150 min/week of moderate physical activity, or more than 75 min/week of vigorous activity)
• Patients who are functional illiterates
• Patients with history or clinical diagnosis of neurological diseases
• Patients with severe psychiatric symptoms
• Patients taking antidepressants
• Patients with visual and/or hearing impairments that prevent participation